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26564 Sigma-Aldrich

Chlorotripyrrolidinophosphonium hexafluorophosphate

≥98.0% (AT)

Synonym: PyCloP

  • CAS Number 133894-48-1

  • Linear Formula C12H24ClN3P · PF6

  • Molecular Weight 421.73

  •  Beilstein/REAXYS Number 6842341

  •  MDL number MFCD00210035

  •  PubChem Substance ID 57648178

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Properties

Related Categories Chemical Biology, Chemical Synthesis, Coupling, Peptide Coupling, Peptide Synthesis and Peptide Chemistry,
InChI Key   BSCYRXJVGSZNKX-UHFFFAOYSA-N
assay   ≥98.0% (AT)
storage temp.   2-8°C

Description

Application

Reagent for:
Peptide coupling reactions and synthesis of coupling reagents
Sequence selective peptide recognition
Synthesis of condensing reagents
Synthesis of heterocyclic β-sheet ligands

Packaging

5, 25 g in glass bottle

Other Notes

Crystalline reagent for peptide coupling of N-alkylated N-Fmoc and N-Z amino acids in high yield and without racemization.

Safety & Documentation

Safety Information

Symbol 
GHS05  GHS05
Signal word 
Danger
Hazard statements 
Precautionary statements 
RIDADR 
UN 1759 8 / PGII
WGK Germany 
3

Documents

Certificate of Analysis

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Protocols & Articles

Articles

Phosphonium Salts

Phosphonium salts are powerful and easy-to-use peptide coupling reagents that allow in situ generation of active esters. After the recognition of chlorotris(dimethylamino)phosphonium as the activatin...
Matthias Junkers
ChemFiles 2007, 7.2, 8.
Keywords: Peptide synthesis

Related Content

COMU – Safer and More Efficient Peptide Coupling Reagent

Peptide synthesis relies heavily on efficient and reliable coupling reagents. A low tendency for racemization is a key requirement. This is especially true for solid phase peptide synthesis—quantitat...
Keywords: Building blocks, Calorimetry, Condensations, Coupling reactions, Epimerizations, PEGylations, Peptide synthesis, Racemizations, Solid phase peptide synthesis, Solvents

Peer-Reviewed Papers
15

References

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