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269697 Sigma-Aldrich

Ethyl 4,4,4-trifluorocrotonate

98%

Synonym: Ethyl 4,4,4-trifluoro-2-butenoate

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Properties

Related Categories Building Blocks, C6 to C7, Carbonyl Compounds, Chemical Synthesis, Esters,
InChI Key   ZKRJCMKLCDWROR-ONEGZZNKSA-N
assay   98%
refractive index   n20/D 1.3601 (lit.)
bp   114-115 °C(lit.)
density   1.125 g/mL at 25 °C (lit.)

Description

General description

The Michael reaction between ethyl 4,4,4-trifluorocrotonate and a Ni(II) complex of the Schiff base of glycine with (S)-o-[N-(N-benzylprolyl)amino]benzophenone was studied.

Application

Ethyl 4,4,4-trifluorocrotonate was used in the synthesis of (2S,3S)-3-methyl- and (2S,3S)-3-trifluoromethylpyroglutamic acid. It undergoes diastereoselective Michael addition reaction with ethyl crotonate.

Packaging

5 g in glass bottle

Safety & Documentation

Safety Information

Symbol 
Signal word 
Warning
Hazard statements 
Precautionary statements 
RIDADR 
UN 3272 3 / PGIII
WGK Germany 
3
Flash Point(F) 
78.8 °F
Flash Point(C) 
26 °C
Protocols & Articles
Peer-Reviewed Papers
15

References

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