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275875 Sigma-Aldrich

4-Aminopyridine

≥99%

Synonym: 4-Pyridinamine, 4-Pyridylamine, 4AP, Fampridine

  • CAS Number 504-24-5

  • Empirical Formula (Hill Notation) C5H6N2

  • Molecular Weight 94.11

  •  Beilstein/REAXYS Number 105782

  •  EC Number 207-987-9

  •  MDL number MFCD00006439

  •  PubChem Substance ID 24856677

  •  NACRES NA.22

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Properties

Related Categories Building Blocks, C5, Chemical Synthesis, Heterocyclic Building Blocks, Pyridines More...
InChI Key   NUKYPUAOHBNCPY-UHFFFAOYSA-N
assay   ≥99%
bp   273 °C (lit.)
mp   155-158 °C (lit.)
solubility   DMF: soluble(lit.)
  DMSO: soluble(lit.)
  THF: soluble(lit.)
  acetone: soluble(lit.)
  acetonitrile: soluble(lit.)
  ethanol: soluble(lit.)
  isopropanol: soluble(lit.)
  methanol: soluble(lit.)
  water: soluble(lit.)
Gene Information   mouse ... Kcna3(16491)
rat ... Grin2a(24409)

Description

General description

4-Aminopyridine (4-AP) blocks the voltage-dependent potassium channels in other nerve membranes. 4-AP is a K+ channel blocker and causes epileptiform activity in in vitro preparations and is a potent convulsant in animals and man.

Application

4-Aminopyridine has been used to study the nerve conduction in fibres of normal rat spinal roots and those demyelinated with diphtheria toxin.

Packaging

1, 5 g in glass bottle

Safety & Documentation

Safety Information

Symbol 
GHS06  GHS06
Signal word 
Danger
Hazard statements 
Precautionary statements 
RIDADR 
UN 2671 6.1 / PGII
WGK Germany 
3
RTECS 
US1750000

Documents

Certificate of Analysis (COA)

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Certificate of Origin (COO)

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Meet Synthia - Retrosynthesis Sofware
Protocols & Articles
Peer-Reviewed Papers
15

References

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