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275875 Sigma-Aldrich

4-Aminopyridine

≥99%

Synonym: 4-Pyridinamine, 4-Pyridylamine, 4AP, Fampridine

  • CAS Number 504-24-5

  • Empirical Formula (Hill Notation) C5H6N2

  • Molecular Weight 94.11

  •  Beilstein/REAXYS Number 105782

  •  EC Number 207-987-9

  •  MDL number MFCD00006439

  •  PubChem Substance ID 24856677

  •  NACRES NA.22

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Properties

Related Categories Building Blocks, C5, Chemical Synthesis, Heterocyclic Building Blocks, Pyridines More...
Quality Level   100
assay   ≥99%
bp   273 °C (lit.)
mp   155-158 °C (lit.)
solubility   DMF: soluble(lit.)
  DMSO: soluble(lit.)
  THF: soluble(lit.)
  acetone: soluble(lit.)
  acetonitrile: soluble(lit.)
  ethanol: soluble(lit.)
  isopropanol: soluble(lit.)
  methanol: soluble(lit.)
  water: soluble(lit.)
SMILES string   Nc1ccncc1
InChI   1S/C5H6N2/c6-5-1-3-7-4-2-5/h1-4H,(H2,6,7)
InChI key   NUKYPUAOHBNCPY-UHFFFAOYSA-N
Gene Information   human ... KCNA1(3736), KCNA10(3744), KCNA2(3737), KCNA3(3738), KCNA4(3739), KCNA5(3741), KCNA6(3742), KCNA7(3743), KCNB1(3745), KCNB2(9312), KCNC1(3746), KCNC2(3747), KCNC3(3748), KCNC4(3749), KCND1(3750), KCND2(3751), KCND3(3752), KCNF1(3754), KCNG1(3755), KCNG2(26251), KCNG3(170850), KCNG4(93107), KCNH1(3756), KCNH2(3757), KCNH3(23416), KCNH4(23415), KCNH5(27133), KCNH6(81033), KCNH7(90134), KCNH8(131096), KCNQ1(3784), KCNQ2(3785), KCNQ3(3786), KCNQ4(9132), KCNQ5(56479), KCNS1(3787), KCNS2(3788), KCNS3(3790), KCNV1(27012), KCNV2(169522)
mouse ... Kcna3(16491)
rat ... Grin2a(24409)

Description

General description

4-Aminopyridine (4-AP) blocks the voltage-dependent potassium channels in other nerve membranes. 4-AP is a K+ channel blocker and causes epileptiform activity in in vitro preparations and is a potent convulsant in animals and man.

Application

4-Aminopyridine has been used to study the nerve conduction in fibres of normal rat spinal roots and those demyelinated with diphtheria toxin.

Packaging

1, 5 g in glass bottle

Safety & Documentation

Safety Information

Symbol 
Signal word 
Danger
Hazard statements 
RIDADR 
UN 2671 6.1 / PGII
WGK Germany 
WGK 3
RTECS 
US1750000
Flash Point(F) 
312.8 °F
Flash Point(C) 
156 °C

Documents

Certificate of Analysis (COA)

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Certificate of Origin (COO)

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Meet Synthia - Retrosynthesis Sofware
Protocols & Articles
Peer-Reviewed Papers
15

References

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