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281611 Aldrich

Tamoxifen

96%

Synonym: (Z)-1-(p-Dimethylaminoethoxyphenyl)-1,2-diphenyl-1-butene, trans-2-[4-(1,2-Diphenyl-1-butenyl)phenoxy]-N,N-dimethylethylamine

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Properties

InChI Key   NKANXQFJJICGDU-QPLCGJKRSA-N
assay   96%
mp   97-98 °C (lit.)
Gene Information   human ... ESR1(2099)

Description

Biochem/physiol Actions

Protein kinase C inhibitor. Induces apoptosis in human malignant glioma cell lines. Tamoxifen and its metabolite 4-hydroxytamoxifen are selective estrogen response modifiers (SERMs) that act as estrogen antagonists in mammary gland. Blocks estradiol-stimulated VEGF production in breast tumor cells.

Safety & Documentation

Safety Information

Symbol 
GHS08  GHS08
Signal word 
Danger
Hazard statements 
Precautionary statements 
WGK Germany 
3
RTECS 
KR5919600

Documents

Certificate of Analysis

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Protocols & Articles
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replaced by

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Description

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T5648 Tamoxifen, ≥99%

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