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284785 Sigma-Aldrich

(S)-(+)-6-Methoxy-α-methyl-2-naphthaleneacetic acid

98%

Synonym: (S)-(+)-2-(6-Methoxy-2-naphthyl)propionic acid, Naproxen

  • CAS Number 22204-53-1

  • Linear Formula CH3OC10H6CH(CH3)CO2H

  • Molecular Weight 230.26

  •  Beilstein/REAXYS Number 3591068

  •  EC Number 244-838-7

  •  MDL number MFCD00010500

  •  PubChem Substance ID 24857178

  •  NACRES NA.22

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Properties

Related Categories Arachidonic Acid Cascade, Asymmetric Synthesis, Carboxylic Acids, Cell Biology, Cell Signaling and Neuroscience,
Quality Level   200
assay   98%
optical activity   [α]25/D +66°, c = 1 in chloroform
mp   152-154 °C (lit.)
SMILES string   COc1ccc2cc(ccc2c1)[C@H](C)C(O)=O
InChI   1S/C14H14O3/c1-9(14(15)16)10-3-4-12-8-13(17-2)6-5-11(12)7-10/h3-9H,1-2H3,(H,15,16)/t9-/m0/s1
InChI key   CMWTZPSULFXXJA-VIFPVBQESA-N
Gene Information   human ... MAPK14(1432), PTGS1(5742), PTGS2(5743)
rat ... Alox5(25290), Ptgs1(24693)

Description

General description

(S)-(+)-6-Methoxy-α-methyl-2-naphthaleneacetic acid is a nonsteroidal anti-inflammatory molecule (NSAID). The (S)-enantiomer is 30 times more active than the (R)-enantiomer.

Application

(S)-(+)-6-Methoxy-α-methyl-2-naphthaleneacetic acid can be used as a chiral ligand in the synthesis of organotin (IV) carboxylate metal complexes.

Packaging

5, 25 g in poly bottle

Biochem/physiol Actions

Non-selective cyclooxygenase (COX-1 and COX-2) inhibitor.

Safety & Documentation

Safety Information

Symbol 
GHS06  GHS06
Signal word 
Danger
Hazard statements 
Precautionary statements 
RIDADR 
UN 2811 6.1 / PGIII
WGK Germany 
WGK 3
RTECS 
UF5275000
Flash Point(F) 
Not applicable
Flash Point(C) 
Not applicable

Documents

Certificate of Analysis (COA)

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Certificate of Origin (COO)

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Protocols & Articles
Peer-Reviewed Papers
15

References

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