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300764 Sigma-Aldrich

1,2,3,4-Tetrahydro-9H-pyrido[3,4-b]indole

98%

Synonym: Noreleagnine, THBC, Tetrahydronorharman, Tryptoline

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Properties

Related Categories Building Blocks, C11, Chemical Synthesis, Heterocyclic Building Blocks, Indoles More...
InChI Key   CFTOTSJVQRFXOF-UHFFFAOYSA-N
assay   98%
mp   206-208 °C (lit.)
Gene Information   rat ... Htr2a(29595), Htr2c(25187)

Description

General description

Ozonolysis of the enamine bond of 1,2,3,4-tetrahydro-9H-pyrido[3,4-b]indole derivatives was studied.

Application

• Reactant for synthesis of the indolyl-β-carboline alkaloid eudistomin U via IBX mediated room temperature oxidative aromatization
• Reactant for preparation of neuroprotective HDAC6 inhibitors
• Reactant for preparation of aminofuranopyrimidines as EGFR and Aurora A kinase inhibitors
• Reactant for preparation of inhibitors of CDK4
• Reactant for preparation of tetrahydrocarboline derivatives of as human 5-HT5A receptor ligands
• Reactant for preparation of 5-(diaminomethyl)-2,4-aminopyrimidines as dihydrofolate reductase inhibitors and antibacterial agents

1,2,3,4-Tetrahydro-9H-pyrido[3,4-b]indole was employed in alkaloid synthesis and in studies on neurodegenerative diseases.

Packaging

1, 5 g in glass bottle

Other Notes

Tandem Mass Spectrometry data independently generated by Scripps Center for Metabolomics is available to view or download in PDF. 300764.pdf Tested metabolites are featured on Scripps Center for Metabolomics METLIN Metabolite Database. To learn more, visit sigma.com/metlin.

Safety & Documentation

Safety Information

Symbol 
GHS07  GHS07
Signal word 
Warning
Hazard statements 
Precautionary statements 
Personal Protective Equipment 
RIDADR 
NONH for all modes of transport
WGK Germany 
3

Documents

Certificate of Analysis

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Protocols & Articles
Peer-Reviewed Papers
15

References

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