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301485 Sigma-Aldrich

1-Chloroethyl chloroformate

98%

Synonym: ACE-Cl

  • CAS Number 50893-53-3

  • Linear Formula CH3CHClOCOCl

  • Molecular Weight 142.97

  •  Beilstein/REAXYS Number 1747601

  •  EC Number 256-834-2

  •  MDL number MFCD00000647

  •  PubChem Substance ID 24858191

  •  NACRES NA.22

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Properties

Related Categories Acid Halides, Building Blocks, Carbonyl Compounds, Chemical Synthesis, Organic Building Blocks More...
vapor pressure   3.25 psi ( 20 °C)
assay   98%
refractive index   n20/D 1.422 (lit.)
bp   118-119 °C (lit.)
density   1.325 g/mL at 25 °C (lit.)
storage temp.   2-8°C
SMILES string   CC(Cl)OC(Cl)=O
InChI   1S/C3H4Cl2O2/c1-2(4)7-3(5)6/h2H,1H3
InChI key   QOPVNWQGBQYBBP-UHFFFAOYSA-N

Description

Application

1-Chloroethyl chloroformate was used:
• for N-demethylation reaction during determination of multiple drugs of abuse in biological fluids using capillary electrophoresis with native fluorescence and laser-induced fluorescence detection
• as catalyst in chemoselective desilylation of silyl-protected alcohols
• as reagent in N-demethylation of tertiary amines to produce drug metabolite reference material for forensic toxicological applications
• as reagent to cleave benzhydryl groups from amines

Packaging

5, 25 g in glass bottle

Safety & Documentation

Safety Information

Symbol 
Signal word 
Danger
Hazard statements 
RIDADR 
UN 2742 6.1(3)(8) / PGII
WGK Germany 
3
Flash Point(F) 
104 °F
Flash Point(C) 
40 °C

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Protocols & Articles
Peer-Reviewed Papers
15

References

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