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302309 Sigma-Aldrich

2-Cyanoethyl N,N-diisopropylchlorophosphoramidite

Cl 13.5-15.5 %

Synonym: Chloro(diisopropylamino)-β-cyanoethoxyphosphine

  • CAS Number 89992-70-1

  • Linear Formula [(CH3)2CH]2NP(Cl)OCH2CH2CN

  • Molecular Weight 236.68

  •  Beilstein/REAXYS Number 3588525

  •  MDL number MFCD00011544

  •  PubChem Substance ID 24858245

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Properties

Related Categories Building Blocks, Chemical Biology, Chemical Synthesis, Coupling Reagents, Nucleoside Chemistry,
InChI Key   QWTBDIBOOIAZEF-UHFFFAOYSA-N
composition   Cl, 13.5-15.5%
density   1.061 g/mL at 25 °C (lit.)
storage temp.   −20°C

Description

Application

2-Cyanoethyl N,N-diisopropylchlorophosphoramidite was employed:
• for selective monophosphorylation of carbohydrates and nucleosides
• for conversion of protected ribonucleosides to phosphoramidites
• as phosphitylating reagent for 3′-hydroxyl groups in the synthesis of oligodeoxyribonucleotides
• in a scalable, solution-phase oligonucleotide synthesis employing phosphoramidite chemistry and DMT-, iBu- and Bz-protected monomers. Intermediates were isolated by extraction without further purification

Packaging

1, 5 g in glass bottle

250 mg in glass bottle

Safety & Documentation

Safety Information

Symbol 
Signal word 
Danger
Hazard statements 
Precautionary statements 
RIDADR 
UN 2845 4.2
WGK Germany 
3
Flash Point(F) 
230 °F
Flash Point(C) 
110 °C

Documents

Certificate of Analysis

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Protocols & Articles
Peer-Reviewed Papers
15

References

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