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309567 Sigma-Aldrich

(Methoxymethyl)triphenylphosphonium chloride

97%

  • CAS Number 4009-98-7

  • Linear Formula (C6H5)3P(Cl)CH2OCH3

  • Molecular Weight 342.80

  •  Beilstein/REAXYS Number 3599844

  •  EC Number 223-664-5

  •  MDL number MFCD00011800

  •  PubChem Substance ID 24858739

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Properties

Related Categories C-C Bond Formation, Chemical Synthesis, Olefination, Synthetic Reagents, Wittig Reagents More...
Quality Level   100
assay   97%
reaction suitability   reaction type: C-C Bond Formation
mp   185-195 °C (dec.) (lit.)
SMILES string   [Cl-].COC[P+](c1ccccc1)(c2ccccc2)c3ccccc3
InChI   1S/C20H20OP.ClH/c1-21-17-22(18-11-5-2-6-12-18,19-13-7-3-8-14-19)20-15-9-4-10-16-20;/h2-16H,17H2,1H3;1H/q+1;/p-1
InChI key   SJFNDMHZXCUXSA-UHFFFAOYSA-M

Description

Application

(Methoxymethyl)triphenylphosphonium chloride is a Wittig reagent that reacts with aldehydes and ketones to give substituted alkenes. This Wittig reaction finds application as the key step in the synthesis of:
• Antimalarial drug, (+)-artemisinin.
• Substituted quinolines.
• Akuammiline alkaloid picrinine.
• 7H-pyrrolo[2,3-d]pyrimidine derivatives for signal transducers and activators of transcription 6 (STAT6) inhibitors.

Packaging

25, 100 g in glass bottle

Safety & Documentation

Safety Information

Symbol 
GHS07  GHS07
Signal word 
Warning
Hazard statements 
Precautionary statements 
Target organs 
Respiratory system
Personal Protective Equipment 
RIDADR 
NONH for all modes of transport
WGK Germany 
WGK 3
Flash Point(F) 
Not applicable
Flash Point(C) 
Not applicable

Documents

Certificate of Analysis (COA)

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Protocols & Articles
Peer-Reviewed Papers
15

References

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