EMAIL THIS PAGE TO A FRIEND
320293 Sigma-Aldrich

Dimethyl sulfate

≥99%

Synonym: Sulfuric acid dimethyl ester

  • CAS Number 77-78-1

  • Linear Formula (CH3O)2SO2

  • Molecular Weight 126.13

  •  Beilstein/REAXYS Number 635994

  •  EC Number 201-058-1

  •  MDL number MFCD00008416

  •  PubChem Substance ID 24859257

  •  NACRES NA.22

Purchase

Properties

Related Categories Alkyl Transfer, Arbidol, C-X Bond Formation (Non-Halogen), Chemical Synthesis, Chemicals for the synthesis of candidate COVID-19 treatments,
Quality Level   200
vapor density   4.3 (vs air)
vapor pressure   0.7 mmHg ( 25 °C)
assay   ≥99%
form   liquid
autoignition temp.   923 °F
refractive index   n20/D 1.386 (lit.)
bp   188 °C (lit.)
mp   −32 °C (lit.)
density   1.333 g/mL at 25 °C (lit.)
SMILES string   COS(=O)(=O)OC
InChI   1S/C2H6O4S/c1-5-7(3,4)6-2/h1-2H3
InChI key   VAYGXNSJCAHWJZ-UHFFFAOYSA-N

Description

Application

Dimethyl sulfate is a powerful methylating reagent for the methylation of carboxylic acids, alcohols, phenols, lactams, oximes, hydroxylamines, and hydroperoxides. It can be used as a reagent for the preparation of N-methyl alkyl- and aryl-substituted amines, amides, and quaternary ammonium salts. Dimethyl sulfate is also used in the methylation of sulfur-containing compounds to synthesize sulfides and sulfonium ions.
It can also be used as a reagent:       
•  For the preparation of quaternary ammonium acrylic monomer as a potent antibacterial agent by the quaternization of 2-dimethylamino ethyl methacrylate.       
•  Along with dimethyl sulfoxide for the synthesis of epoxides from aldehydes and ketones via formation of trimethylsulfonium cation.      
• To prepare an oxygenate additive for diesel by the methylation of glycerol.

Packaging

1 L in Sure/Seal™

Safety & Documentation

Safety Information

Symbol 
Signal word 
Danger
RIDADR 
UN1595 - class 6.1 - PG 1 - Dimethyl sulphate
WGK Germany 
WGK 3
RTECS 
WS8225000

Documents

Certificate of Analysis (COA)

Please Enter a Lot Number

Certificate of Origin (COO)

Please Enter a Lot Number
Protocols & Articles
Peer-Reviewed Papers
15

References

Related Products

related product

Product #

Description

Add to Cart

908401 1-Methyl-7-nitroisatoic anhydride
913839 2-Methylnicotinic acid imidazolide

Technical Service:

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Bulk Ordering & Pricing:

Need larger quantities for your development, manufacturing or research applications?