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325244 Aldrich

1,1,1,3,3,3-Hexafluoro-2-propanol

≥99.5%

Synonym: HFP, Hexafluoroisopropanol

  • CAS Number 920-66-1

  • Linear Formula (CF3)2CHOH

  • Molecular Weight 168.04

  •  Beilstein Registry Number 1841007

  •  EC Number 213-059-4

  •  MDL number MFCD00011651

  •  PubChem Substance ID 24859495

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Properties

Related Categories Alcohols, Building Blocks, C2 to C6, Chemical Synthesis, Organic Building Blocks,
InChI Key   BYEAHWXPCBROCE-UHFFFAOYSA-N
assay   ≥99.5%
refractive index   n20/D 1.275(lit.)
bp   59 °C(lit.)
mp   −4 °C(lit.)
density   1.596 g/mL at 25 °C(lit.)

Description

Application

1,1,1,3,3,3-Hexafluoro-2-propanol (Hexafluoroisopropanol) was used as:
• a crucial additive to improve the enantioselectivity of Friedel-Crafts alkylation of pyrrole with isatins
• esterification reagent for the determination of aromatic acids in tissue by GLC and electron capture detection
• additive which accelerates the Pictet-Spengler synthesis of tetrahydroisoquinolines in water catalyzed by a Bronsted acid-surfactant combined catalyst (BASC)

General description

1,1,1,3,3,3-Hexafluoro-2-propanol (HFIP) is an efficient hydrogen-bond donor and highly polar solvent for a reactions with Si-capped Π donors. HFIP is a solvent and its ability to induce self-assembly of an aromatic dipeptide was evaluated. HFIP-induced coacervation in aqueous mixed systems of catanionic surfactants of dodecyltrimethylammonium bromide (DTAB) and sodium dodecyl sulfate (SDS) was investigated.

Safety & Documentation

Safety Information

Symbol 
Signal word 
Danger
Hazard statements 
RIDADR 
UN 3265 8 / PGII
WGK Germany 
2
RTECS 
UB6450000

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Protocols & Articles

Articles

Hexafluoroalcohol-functionalized Methacrylate Monomers for Lithographic/Nanopatterning Materials

To keep pace with Moore′s Law, there is a continuing need in the semiconductor industry to achieve higher circuit density in microelectronic devices. The principle means of defining high resolution c...
Daniel P. Sanders, Ratnam Sooriyakumaran, Richard A. DiPietro*
Material Matters Volume 6 Article 1
Keywords: Applications, Capabilities, Chemical reactions, Formulations, Microelectronics, Polymerization reactions, Semiconductor, Solvents, Type, transformation

Peer-Reviewed Papers
15

References

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