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328820 Sigma-Aldrich

4-Fluorophenylmagnesium bromide solution

1.0 M in THF

  • CAS Number 352-13-6

  • Linear Formula FC6H4MgBr

  • Molecular Weight 199.30

  •  Beilstein/REAXYS Number 636802

  •  MDL number MFCD00009667

  •  PubChem Substance ID 24859751

  •  NACRES NA.22

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Properties

Related Categories Aryl, Chemical Synthesis, Grignard Reagents, Organometallic Reagents
reaction suitability   reaction type: Grignard Reaction
concentration   1.0 M in THF
density   1.021 g/mL at 25 °C
SMILES string   Fc1ccc([Mg]Br)cc1
InChI   1S/C6H4F.BrH.Mg/c7-6-4-2-1-3-5-6;;/h2-5H;1H;/q;;+1/p-1
InChI key   QYBFFRXNNFXREA-UHFFFAOYSA-M

Description

Application

4-Fluorophenylmagnesium bromide solution (Grignard reagent) can be used as a reagent in the synthesis of:
• Useful key intermediate in the synthesis of paroxetine.
• Arylsulfides via cross-coupling reaction with thiols.
• 4-Arylmethyl-1-phenylpyrazole and 4-aryloxy-1-phenylpyrazole derivatives as androgen receptor antagonists.
• Grignard intermediate for preparing aprepitant.

Packaging

100, 800 mL in Sure/Seal™

Safety & Documentation

Safety Information

Signal word 
Danger
Hazard statements 
Target organs 
Respiratory system
Supplemental Hazard Statements 
EUH014 - EUH019
RIDADR 
UN 2924 8(3) / PGII
WGK Germany 
WGK 3

Documents

Certificate of Analysis (COA)

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Certificate of Origin (COO)

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Protocols & Articles
Peer-Reviewed Papers
15

References

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