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344591 Sigma-Aldrich

2,3,5,6-Tetrafluoro-4-pyridinecarbonitrile

99%

  • CAS Number 16297-07-7

  • Empirical Formula (Hill Notation) C6F4N2

  • Molecular Weight 176.07

  •  MDL number MFCD00075302

  •  PubChem Substance ID 24861263

  •  NACRES NA.22

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Properties

Related Categories Building Blocks, C6, Chemical Synthesis, Fluorinated Building Blocks, Heterocyclic Building Blocks,
Quality Level   100
assay   99%
mp   66-68 °C (lit.)
SMILES string   Fc1nc(F)c(F)c(C#N)c1F
InChI   1S/C6F4N2/c7-3-2(1-11)4(8)6(10)12-5(3)9
InChI key   JXISJBVJNUKKBK-UHFFFAOYSA-N

Description

General description

2,3,5,6-Tetrafluoro-4-pyridinecarbonitrile is a perfluorinated heteroaromatic compound. 2,3,5,6-Tetrafluoro-4-pyridinecarbonitrile (tetrafluoro-4-cyanopyridine) reacts with 1,3-dicarbonyl systems to yield the corresponding [5,6]-ring fused furo derivatives. 2,3,5,6-Tetrafluoro-4-pyridinecarbonitrile (4-cyanotetrafluoropyridine) reacts with amidines to yield [6,6]-fused pyrimidinopyridine system via nucleophilic substitution at the C-3 position of the pyridine ring followed by intramolecular cyclization onto the pendant cyano group. Reaction of 2,3,5,6-tetrafluoro-4-pyridinecarbonitrile (4-cyanotetrafluoropyridine) with sulfur centred nucleophiles has been reported.

Application

2,3,5,6-Tetrafluoro-4-pyridinecarbonitrile may be used in the preparation of 2-anilino-3,5,6-trifluoroisonicotinonitrile.

Packaging

1 g in glass bottle

Safety & Documentation

Safety Information

Symbol 
GHS07  GHS07
Signal word 
Warning
Target organs 
Respiratory system
Personal Protective Equipment 
RIDADR 
NONH for all modes of transport
WGK Germany 
WGK 3
Flash Point(F) 
Not applicable
Flash Point(C) 
Not applicable

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Protocols & Articles
Peer-Reviewed Papers
15

References

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