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348074 Sigma-Aldrich

2-Chloro-4-fluorobenzaldehyde

97%

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Properties

Related Categories Aldehydes, Aryl Fluorinated Building Blocks, Building Blocks, C7, Carbonyl Compounds,
assay   97%
bp   118-120 °C/50 mmHg (lit.)
mp   60-63 °C (lit.)
SMILES string   Fc1ccc(C=O)c(Cl)c1
InChI   1S/C7H4ClFO/c8-7-3-6(9)2-1-5(7)4-10/h1-4H
InChI key   KMQWNQKESAHDKD-UHFFFAOYSA-N

Description

General description

2-Chloro-4-fluorobenzaldehyde is a halogen substituted benzaldehyde.

Application

2-Chloro-4-fluorobenzaldehyde may be used in the synthesis of substituted α-cyanocinnamic acid, via Knoevenagel condensation reaction. It may be used in the synthesis of 2-(2-benzimidazolyl)-3-(2-chloro-4-fluorophenyl)acrylonitrile.

Packaging

1, 5 g in glass bottle

Safety & Documentation

Safety Information

Symbol 
GHS07  GHS07
Signal word 
Warning
Hazard statements 
Precautionary statements 
Target organs 
Respiratory system
Personal Protective Equipment 
RIDADR 
NONH for all modes of transport
WGK Germany 
WGK 3
Flash Point(F) 
Not applicable
Flash Point(C) 
Not applicable

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Protocols & Articles

Articles

Knoevenagel Condensation Reaction

The Knoevenagel Condensation Reaction is a classic organic synthesis, described by Emil Knoevenagel in the 1890’s. The Knoevenagel reaction is a modified Aldol Condensation with a nucleophilic additi...
Keywords: Aldol condensation, C-C bond formation, Condensations, Dehydration reaction, Knoevenagel Condensation, Nucleophilic additions, Organic synthesis

Peer-Reviewed Papers
15

References

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