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  • 359270 - Sodium tert-butoxide

359270 Sigma-Aldrich

Sodium tert-butoxide


  • CAS Number 865-48-5

  • Linear Formula NaOC(CH3)3

  • Molecular Weight 96.10

  •  Beilstein Registry Number 3654215

  •  EC Number 212-741-9

  •  MDL number MFCD00040575

  •  PubChem Substance ID 24862063




1.5 kg in glass bottle

2.5 kg in poly bottle

5, 25, 100, 500 g in poly bottle


Sodium tert-butoxide may be used as a safe and effective alternative to sodium hydride for the coupling of hydroxyethyl adenine with diethyl p-toluenesulfonyloxymethanephosphonate to form 9-[2-(diethylphosphonomethoxy)ethyl]adenine (diethyl-PMEA), which is a key intermediate to prepare adefovir dipivoxil.
It can also be used:
• To facilitate the coupling of aryl halides with benzene derivatives in the presence of 10-phenanthroline derivative.
• To activate first-row transition-metal pre-catalysts.
• As a base for the amination of aryl chlorides in the presence of a novel palladacyclic precatalyst.

Safety & Documentation

Safety Information

Signal word 
Hazard statements 
Supplemental Hazard Statements 
Reacts violently with water.
UN 3206 8(4.2) / PGII
WGK Germany 
Flash Point(F) 
57.2 °F
Flash Point(C) 
14 °C


Certificate of Analysis

Certificate of Origin

Protocols & Articles


A General, Efficient, and Functional-Group-Tolerant Catalyst System for the Palladium-Catalyzed Thioetherification of Aryl Bromides and Iodides

On the basis of mechanism-driven reaction design, a Pd-catalyzed nucleophilic fluorination of aryl bromides and iodides has been developed. The method exhibits a broad substrate scope, especially wit...
Keywords: Catalysis, Chromatography, Fluorinations, Ligands, Reductions

Design and preparation of new palladium precatalysts for C-C and C-N cross-coupling reactions

Good to excellent yields�of aryl trifluoromethyl sulfides, which are an important class of compounds in both the pharmaceutical and agrochemical areas, can be achieved under mild conditions by the Pd...
Keywords: Agrochemicals, Catalysis, Pharmaceutical

Highly Reactive, General and Long-Lived Catalysts for Palladium-Catalyzed Amination of Heteroaryl and Aryl Chlorides, Bromides, and Iodides: Scope and Structure-Activity Relationships

Boronic acids which quickly deboronate under basic conditions, such as polyfluorophenylboronic acid and five- membered 2-heteroaromatic boronic acids, are especially chal- lenging coupling partners f...
Keywords: Ligands

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Peer-Reviewed Papers


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