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361518 Sigma-Aldrich

1-Hydroxypyrene

98%

Synonym: 1-Pyrenol

  • CAS Number 5315-79-7

  • Empirical Formula (Hill Notation) C16H10O

  • Molecular Weight 218.25

  •  MDL number MFCD00044543

  •  PubChem Substance ID 24862229

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Properties

Related Categories Building Blocks, C9 to C20+, Chemical Synthesis, Organic Building Blocks, Oxygen Compounds,
InChI Key   BIJNHUAPTJVVNQ-UHFFFAOYSA-N
assay   98%
mp   179-182 °C (lit.)

Description

General description

1-Hydroxypyrene, as a urinary metabolite, is a marker of polycyclic aromatic hydrocarbons (PAH) exposure. 1-Hydroxypyrene is an important biomarker of exposure to pyrene.

Application

1-Hydroxypyrene is suitable for use in following studies:
• To investigate the fast detection and quantification of 1-hydroxypyrene in tissue extracts from Nereis diversicolor exposed to sediment-associated pyrene by a simple fluorometric method.
• To investigate the effects of genetic polymorphisms of the cytochrome P450 1A1 (CYP1A1) and 2E1 (CYP2E1) and glutathione S-transferases mu (GSTM1) and theta (GSTT1) on urinary 1-hydroxypyrene and 2-naphthol levels in aircraft maintenance workers.
• To examine the the PAH exposure of cokery workers in an Estonian oil shale processing plant.

Packaging

100 mg in clear glass bottle

500 mg in amber glass bottle

Other Notes

Tandem Mass Spectrometry data independently generated by Scripps Center for Metabolomics is available to view or download in PDF. 361518.pdf Tested metabolites are featured on Scripps Center for Metabolomics METLIN Metabolite Database. To learn more, visit sigma.com/metlin.

Safety & Documentation

Safety Information

Symbol 
GHS07  GHS07
Signal word 
Warning
Hazard statements 
Precautionary statements 
Personal Protective Equipment 
RIDADR 
NONH for all modes of transport
WGK Germany 
3

Documents

Certificate of Analysis

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Certificate of Origin

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Meet Synthia - Retrosynthesis Sofware
Protocols & Articles
Peer-Reviewed Papers
15

References

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