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362425 Sigma-Aldrich

2-Chloro-N-methoxy-N-methylacetamide

98%

  • CAS Number 67442-07-3

  • Linear Formula ClCH2CON(OCH3)CH3

  • Molecular Weight 137.56

  •  MDL number MFCD00134232

  •  PubChem Substance ID 24862311

  •  NACRES NA.22

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Properties

Related Categories Amides, Building Blocks, C2 to C7, Carbonyl Compounds, Chemical Synthesis,
InChI Key   SCOJKGRNQDKFRP-UHFFFAOYSA-N
assay   98%
mp   39-41 °C (lit.)
storage temp.   2-8°C

Description

General description

2-Chloro-N-methoxy-N-methylacetamide is a Weinreb amide.

Application

2-Chloro-N-methoxy-N-methylacetamide may be used in the preparation of:
• 2-heptyl-3-hydroxy-4(1H)-quinolone (Pseudomonas quinolone signal or PQS) and structurally related 2-alkyl-4-quinolones having biological activity
• 2-(benzo[d]thiazol-2-ylsulfonyl)-N-methoxy-N-methylacetamide
• α-chloro-ketone, starting reagent for the one-pot synthesis of 2-heptyl-3-hydroxyl-4(1H)-quinolone (PQS), signalling molecule in the quorum sensing of Pseudomonas aeruginosa

Packaging

5, 25 g in glass bottle

Safety & Documentation

Safety Information

Symbol 
GHS07  GHS07
Signal word 
Warning
Hazard statements 
Precautionary statements 
Personal Protective Equipment 
RIDADR 
NONH for all modes of transport
WGK Germany 
3
Flash Point(F) 
219.2 °F
Flash Point(C) 
104 °C

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Protocols & Articles
Peer-Reviewed Papers
15

References

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