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364258 Sigma-Aldrich

3-Aminopropyl-functionalized silica gel

40-63 μm, extent of labeling: ~1 mmol/g NH2 loading



Related Categories Aminopropyl silica gel, Analytical/Chromatography, Chemical Synthesis, Modified Silica Gels, Reagents,
extent of labeling   ~1 mmol/g NH2 loading
  ~9% functionalized
matrix   irregular silica particle platform
matrix active group   NH2 phase
particle size   40-63 μm
pore size   60 Å pore size
surface area   550 m2/g
SMILES string   O[SiH3].CCCN


General description

The product is silica gel functionalized with amino groups. The product (3-Aminopropyl-functionalized silica gel) is 9% functionalized and has 1mmol/g of NH2 loading (extent of labelling). It participates as catalyst in the Knoevenagel condensation reactions.


3-Aminopropyl-functionalized silica gel may be used in the following studies:
• For the separation of polychlorinated biphenyls (PCBs) from lipids by combined supercritical fluid extraction and separation.
• Preparation of the tin complex immobilized on silica gel, a novel, green, highly efficient and heterogeneous reusable catalyst.
• Preparation of silica gel bearing isonicotinamide groups.
• Synthesis of a novel catalytic system including Pd(OAc)2 attached to a bis(oxazoline) ligand that is covalently bonded to 3-mercaptopropyl-functionalized silica gel.
• Useful as a heterogeneous, reusable catalyst for the Knoevenagel condensation.
• For low- and medium-pressure reversed-phase liquid chromatography.


10, 50, 250 g in glass bottle

Safety & Documentation

Safety Information

GHS07  GHS07
Signal word 
Hazard statements 
Precautionary statements 
Target organs 
Respiratory system
NONH for all modes of transport
WGK Germany 


Certificate of Analysis (COA)

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Certificate of Origin (COO)

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Protocols & Articles


Functionalized Silica Gel Scavengers

Sigma-Aldrich Corporation and SiliCycle Inc. have collaborated to offer scientists ultra pure functionalized silica gels for medicinal and parallel chemistry. These silica gels offer several advantag...
Chemfiles Volume 3 Article 5
Keywords: Microwave synthesis, Organic synthesis, Parallel synthesis, Solvents

Knoevenagel Condensation Reaction

The Knoevenagel Condensation Reaction is a classic organic synthesis, described by Emil Knoevenagel in the 1890’s. The Knoevenagel reaction is a modified Aldol Condensation with a nucleophilic additi...
Keywords: Aldol condensation, C-C bond formation, Condensations, Dehydration reaction, Knoevenagel Condensation, Nucleophilic additions, Organic synthesis

Selection Guide for Polymeric Resins in Chromatography & Purification

Sigma-Aldrich carries a vast array of resins, from leading manufacturers; such as, Dow Chemical, Rohm & Haas, Mitsubishi, and Lanxess. Our product line includes adsorbent, ion-exchange (anion / catio...
Keywords: Adsorption, Antibiotics, Combinatorial synthesis, Detergents, Fermentation, Filtration, Hormones, Ion Exchange, Ion exchange resins, Pharmaceutical, Purification, Separation

Peer-Reviewed Papers


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