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365645 Sigma-Aldrich

Andrographolide

98%

  • CAS Number 5508-58-7

  • Empirical Formula (Hill Notation) C20H30O5

  • Molecular Weight 350.45

  •  Beilstein/REAXYS Number 42762

  •  EC Number 226-852-5

  •  MDL number MFCD07778082

  •  PubChem Substance ID 24862550

  •  NACRES NA.22

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Properties

Related Categories Asymmetric Synthesis, Chemical Synthesis, Chiral Building Blocks, Complex Molecules
assay   98%
optical activity   [α]20/D −126°, c = 1.5 in acetic acid
mp   229-232 °C (lit.)
storage temp.   room temp
SMILES string   C[C@@]1(CO)[C@H](O)CC[C@@]2(C)[C@H](C\C=C3/[C@H](O)COC3=O)C(=C)CC[C@H]12
InChI   1S/C20H30O5/c1-12-4-7-16-19(2,9-8-17(23)20(16,3)11-21)14(12)6-5-13-15(22)10-25-18(13)24/h5,14-17,21-23H,1,4,6-11H2,2-3H3/b13-5+/t14-,15-,16+,17-,19+,20+/m1/s1
InChI key   BOJKULTULYSRAS-OTESTREVSA-N

Description

General description

Andrographolide, a bioactive diterpene lactone, is the main constituent of Andrographis paniculata, a plant used in traditional medicines. It is known to have different biological activities such as anti-inflammatory, anti-malarial, anti-cancer and hepatoprotective activity. It also shows potent anti-viral effect against dengue virus.

Packaging

100 mg in clear glass bottle

500 mg in amber glass bottle

Biochem/physiol Actions

Diterpenoid lactone with anti-inflammatory properties. It blocks T-cell proliferation to allogenic stimuli and the chemotactic migration of macrophages induced by complement. Blocks the proliferation of several cancer cell lines in vitro.

Safety & Documentation

Safety Information

Personal Protective Equipment 
RIDADR 
NONH for all modes of transport
WGK Germany 
WGK 3
RTECS 
LU3490750
Flash Point(F) 
Not applicable
Flash Point(C) 
Not applicable

Documents

Certificate of Analysis (COA)

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Certificate of Origin (COO)

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Protocols & Articles
Peer-Reviewed Papers
15

References

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