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  • 372854 - Poly(2-ethyl-2-oxazoline)

372854 Aldrich


average Mw ~200,000, PDI 3‑4

Synonym: PEOX, POx, PetOx, poly 2-ethyloxazoline, polyethyloxazoline



Related Categories Hydrophilic Polymers, Materials Science, Poly(2-ethyl-2-oxazoline), Poly(2-oxazoline), Poly(2-oxazoline) and Polyethylenimine (PEI),
mol wt   average Mw ~200,000
density   1.14 g/mL at 25 °C(lit.)
PDI   3‑4



This Poly(2-ethyl-2-oxazoline) polymer is amorphous and water soluble with good temperature stability. Jordan and coworkers showed biocompatibility, no accumulation in tissue, and rapid clearance from the bloodstream. End-group modified poly(2-ethyl-2-oxazoline)s have been conjugated to peptides, and were shown as versatile alternatives to poly(ethylene glycol) (PEG) for both protein and small drug conjugation.

Potential substitute for poly(vinyl alcohol) and poly(vinyl pyrrolidone). Adhesion promoter in coatings. Heat sealing and remoistenable hot-melt adhesive


100 g in poly bottle

Physical form

N-propionyl substituted linear polyethylenimine

Features and Benefits

Nonionic, water-soluble thermoplastic. Better heat stability than poly(vinyl alcohol). Good melt flow, shear stability and Newtonian characteristics. Water is a room temperature Theta solvent.

Safety & Documentation

Safety Information

NONH for all modes of transport
WGK Germany 
Protocols & Articles


Poly(2-Oxazoline)S: The Versatile Polymer Platform for Biomedicine

Victor R. de la Rosa,1 An Van Den Bulcke,2 and Richard Hoogenboom1* 1Supramolecular Chemistry Group, Department of Organic and Macromolecular Chemistry Ghent University, Krijgslaan 281-S4, 9000 Ghent...
Victor R. de la Rosa, An Van Den Bulcke, and Richard Hoogenboom
Material Matters, 2016, 11.3
Keywords: Adhesion, Adsorption, Amidations, Bacterial conjugations, Biomaterials, Cancer, Catalysis, Click chemistry, Clinical, Cosmetics, Cycloadditions, Degradations, Electron spin resonance, Pharmaceutical, Polymerization reactions, Ring-opening polymerization

Polyelectrolyte Multilayer Films and Membrane Functionalization

Among the many methods for preparing thin films, layer-by-layer (LbL) deposition of complementary polymers has emerged as an especially versatile technique for controlling film thickness and function...
Merlin L. Bruening, Maneesha Adusumilli
Material Matters Volume 6 Number 3
Keywords: Adsorption, Catalysis, Deposition, Diffusion, Digestions, Electrophoresis, Gel electrophoresis, Immobilization, Mass spectrometry, Nanotechnology, Phase transitions, Reductions

Peer-Reviewed Papers


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