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375004 Sigma-Aldrich

2,4-Thiazolidinedione

technical grade, 90%

  • CAS Number 2295-31-0

  • Empirical Formula (Hill Notation) C3H3NO2S

  • Molecular Weight 117.13

  •  Beilstein Registry Number 110700

  •  EC Number 218-941-2

  •  MDL number MFCD00005478

  •  PubChem Substance ID 24863353

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Properties

Related Categories Building Blocks, C3 to C7, Chemical Synthesis, Heterocyclic Building Blocks, Thiazoles More...
grade   technical grade
InChI Key   ZOBPZXTWZATXDG-UHFFFAOYSA-N
assay   90%
mp   125-127 °C (lit.)

Description

Packaging

25, 100 g in poly bottle

Application

2,4-Thiazolidinedione may be used in the synthesis of sixteen 5-arylidene-2,4-thiazolidinediones, via ultrasound-promoted aldol condensation reaction. It may be used as starting material for the synthesis of drugs with antihyperglycemic activity.

General description

2,4-Thiazolidinedione is a well-known peroxisome proliferator-activated receptors (PPAR) activator. Its effect on aging process using kidneys from Fischer 344 rats has been reported. A library of conjugates of 2,4-thiazolidinedione has been synthesized by Knoevenagel condensation followed by reduction using hydrogen gas and Pd/C catalyst. Knoevenagel condensation of various aromatic aldehydes with 2,4-thiazolidinedione in polyethylene glycol-300 has been reported.

Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport
WGK Germany 
3
RTECS 
XJ5775000

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Protocols & Articles
Peer-Reviewed Papers
15

References

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