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377635 Sigma-Aldrich

Octadecyl-functionalized silica gel

200-400 mesh, extent of labeling: 20-22% loading



Related Categories Analytical/Chromatography, Chemical Synthesis, Modified Silica Gels, Octadecyl -C18- silica, Reagents,
extent of labeling   20-22% loading
matrix   irregular silica particle platform
matrix active group   C18 phase
particle size   200-400 mesh
pore size   60 Å pore size
surface area   ~550 m2/g



Octadecyl-functionalized silica gel is generally used as a stationary phase for low- and medium-pressure reversed-phase liquid chromatography.


25, 100 g in poly bottle

Safety & Documentation

Safety Information

Personal Protective Equipment 
NONH for all modes of transport
WGK Germany 
Flash Point(F) 
Not applicable
Flash Point(C) 
Not applicable


Certificate of Analysis (COA)

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Certificate of Origin (COO)

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Frequently Asked Questions

Which document(s) contains shelf-life or expiration date information for a given product?
If available for a given product, the recommended re-test date or the expiration date can be found on the Certificate of Analysis.
How do I get lot-specific information or a Certificate of Analysis?
The lot specific COA document can be found by entering the lot number above under the "Documents" section.
How do I find price and availability?
There are several ways to find pricing and availability for our products. Once you log onto our website, you will find the price and availability displayed on the product detail page. You can contact any of our Customer Sales and Service offices to receive a quote. USA customers: 1-800-325-3010 or view local office numbers.
What is the Department of Transportation shipping information for this product?
Transportation information can be found in Section 14 of the product's (M)SDS.To access the shipping information for this material, use the link on the product detail page for the product.
What is the solubility of Product 377635, Octadecyl-functionalized silica gel?
This product is not soluble. It can be swelled in organic solvents such as methanol or acetonitrile.
What is the pH stability of Product 377635, Octadecyl-functionalized silica gel?
The product is expected to be unstable when used at pH above 7.5.
How canProduct 377635, Octadecyl-functionalized silica gel resin be cleaned of stubborn material?
One can usually start with 40-50% chloroform in methanol and see if that cleans the resin. If not, try increasing the chloroform content gradually until it is 100%.
How is Product 377635, Octadecyl-functionalized silica gel, prepared?
It is prepared by the reaction of silica gel with n-octadecyltrichlorosilane. After hydrolysis of the unreacted chloro groups, silanol groups on the silica are blocked with trimethylsilyl groups.
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