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379115 Sigma-Aldrich

DCC

1.0 M in methylene chloride

Synonym: N,N′-Dicyclohexylcarbodiimide solution

  • CAS Number 538-75-0

  • Linear Formula C6H11N=C=NC6H11

  • Molecular Weight 206.33

  •  MDL number MFCD00011659

  •  PubChem Substance ID 24863614

  •  NACRES NA.22

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Properties

Related Categories Carbodiimides, Chemical Biology, Chemical Synthesis, Coupling, Peptide Coupling,
concentration   1.0 M in methylene chloride
density   1.247 g/mL at 25 °C
SMILES string   C1CCC(CC1)N=C=NC2CCCCC2
InChI   1S/C13H22N2/c1-3-7-12(8-4-1)14-11-15-13-9-5-2-6-10-13/h12-13H,1-10H2
InChI key   QOSSAOTZNIDXMA-UHFFFAOYSA-N
Gene Information   human ... EPHX2(2053)
mouse ... Ephx2(13850)

Description

Application

DCC (N,N′-Dicyclohexylcarbodiimide) is mainly used to mediate peptide coupling and also to activate carboxylic acids for esterification.

Packaging

100, 800 mL in Sure/Seal™

Safety & Documentation

Safety Information

Symbol 
Signal word 
Danger
RIDADR 
UN 2922 6.1(8) / PGII
WGK Germany 
3
Flash Point(F) 
190.4 °F
Flash Point(C) 
88 °C
Protocols & Articles

Articles

Carbodiimides

Carbodiimide-mediated peptide coupling remains to the most frequently used technique. As a major advantage, carbodiimides do not require prior activation of the carboxylic acid. Dicyclohexylcarbodiim...
Matthias Junkers
Aldrich ChemFiles 2007, 7.2, 5.
Keywords: Cyclizations, Peptide synthesis, Solid phase peptide synthesis

Peer-Reviewed Papers
15

References

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