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380709 Sigma-Aldrich

Benzyl 4-hydroxybenzoate

99%

Synonym: 4-Hydroxybenzoic acid benzyl ester, Benzyl paraben

  • CAS Number 94-18-8

  • Linear Formula HOC6H4CO2CH2C6H5

  • Molecular Weight 228.24

  •  Beilstein/REAXYS Number 2115995

  •  EC Number 202-311-9

  •  MDL number MFCD00016471

  •  PubChem Substance ID 24863764

  •  NACRES NA.22

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Properties

Related Categories Building Blocks, C12 to C63, Carbonyl Compounds, Chemical Synthesis, Esters,
assay   99%
mp   109-112 °C (lit.)
solubility   ethanol: soluble 25 mg/mL, clear, colorless
storage temp.   room temp
SMILES string   Oc1ccc(cc1)C(=O)OCc2ccccc2
InChI   1S/C14H12O3/c15-13-8-6-12(7-9-13)14(16)17-10-11-4-2-1-3-5-11/h1-9,15H,10H2
InChI key   MOZDKDIOPSPTBH-UHFFFAOYSA-N

Description

General description

Benzyl 4-hydroxybenzoate (Paraben, Benzyl Paraben) is an ester of para-hydroxy benzoic acid. It has been added to various cosmetics and personal care products as a preservative. Its quantification in cosmetics has been reported by HPLC methods. Microwave assisted synthesis of benzyl 4-hydroxybenzoate by reaction between (4-hydroxybenzoic) acid and K2CO3 in presence of phase transfer catalyst has been reported. It is an endocrine disrupting chemical (EDC). It is a promising candidate for use in pharmaceutical and personal care products. Its visible-light assisted photosensitized degradation in homogeneous aqueous solution of 4,4′,4′′,4′′′-(porphine-5,10,15,20-tetrayl)tetrakis(benzenesulphonic acid) has been investigated.

Application

Benzyl 4-hydroxybenzoate may be used as internal standard for the simultaneous analysis of non-steroidal anti-inflammatory drugs in human plasma and urine using microextraction by packed sorbent and HPLC method. It may be employed as internal standard for the HPLC determination of rutin, kaempferol, genistein, formononetin and biochanin A in Ononis spinosu roots.

Packaging

100 g in poly bottle

Safety & Documentation

Safety Information

Symbol 
GHS09  GHS09
Signal word 
Warning
Hazard statements 
Personal Protective Equipment 
RIDADR 
UN 3077 9 / PGIII
WGK Germany 
WGK 3
Flash Point(F) 
Not applicable
Flash Point(C) 
Not applicable

Documents

Certificate of Analysis (COA)

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Certificate of Origin (COO)

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Protocols & Articles

Articles

HPLC Analysis of Cosmetic Preservatives on Ascentis® Express RP-Amide

From our library of Articles, Sigma-Aldrich presents HPLC Analysis of Cosmetic Preservatives on Ascentis® Express RP-Amide
Keywords: Chromatography, Cosmetics, High performance liquid chromatography

Peer-Reviewed Papers
15

References

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