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381551 Sigma-Aldrich

7-Isopropoxy-3-phenyl-4H-1-benzopyran-4-one

97%

Synonym: Ipriflavone

  • CAS Number 35212-22-7

  • Empirical Formula (Hill Notation) C18H16O3

  • Molecular Weight 280.32

  •  MDL number MFCD00221719

  •  PubChem Substance ID 24863826

  •  NACRES NA.22

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Properties

Related Categories Building Blocks, Chemical Synthesis, Heterocyclic Building Blocks, Pyrans
Quality Level   100
assay   97%
mp   116-120 °C (lit.)
SMILES string   CC(C)Oc1ccc2c(OC=C(C2=O)c3ccccc3)c1
InChI   1S/C18H16O3/c1-12(2)21-14-8-9-15-17(10-14)20-11-16(18(15)19)13-6-4-3-5-7-13/h3-12H,1-2H3
InChI key   SFBODOKJTYAUCM-UHFFFAOYSA-N
Gene Information   rat ... Alpl(25586)

Description

General description

7-Isopropoxy-3-phenyl-4H-1-benzopyran-4-one (Ipriflavone), a synthetic flavonoid, is reported to stimulate the activity of osteoblasts. It is reported to promote the deposition of calcium and the formation of mineralized nodules by newborn rat calvarial osteoblast-like (ROB) cells as well as the activity of alkaline phosphatase. Ipriflavone, an isoflavone derivative, is a new drug used to decrease bone loss in osteoporosis.

Application

7-Isopropoxy-3-phenyl-4H-1-benzopyran-4-one (Ipriflavone) has been used as a model drug in a study to functionalize the mesoporous bioactive glasses (MBG). Study suggested that since ipriflavone is a hydrophobic anti-osteoporotic drug, it easily attaches to the surface of MBG and results in long-term drug delivery.

Packaging

5 g in glass bottle

Safety & Documentation

Safety Information

Personal Protective Equipment 
RIDADR 
NONH for all modes of transport
WGK Germany 
WGK 2
RTECS 
DJ3100500
Flash Point(F) 
Not applicable
Flash Point(C) 
Not applicable

Documents

Certificate of Analysis (COA)

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Meet Synthia - Retrosynthesis Sofware
Protocols & Articles
Peer-Reviewed Papers
15

References

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