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383449 Sigma-Aldrich

3-Formylchromone

97%

Synonym: 4-Oxo-4H-1-benzopyran-3-carboxaldehyde

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Properties

Related Categories Aldehydes, Benzopyrans, Building Blocks, C10-C12, Carbonyl Compounds,
assay   97%
mp   151-153 °C (lit.)
storage temp.   room temp
SMILES string   O=CC1=COc2ccccc2C1=O
InChI   1S/C10H6O3/c11-5-7-6-13-9-4-2-1-3-8(9)10(7)12/h1-6H
InChI key   FSMYWBQIMDSGQP-UHFFFAOYSA-N
Gene Information   human ... PTPN1(5770)

Description

General description

Electrospray ionization mass spectrometry (ESI-MS) of protonated 3-formylchromone (3-FC) shows loss of H2 as a major fragmentation route to yield a ketene cation, which on reaction with water forms a protonated carboxylic acid. The invivo salubrious effects of 3-FC against nitrosodiethylamine (NDEA) mediated early hepatocellular carcinogenesis has been investigated. Synthesis and characterization of 3-FC and its derivatives has been reported.

Application

3-Formylchromone may be used in the following studies:
• Preparation of library of novel (E)-3-(2-arylcarbonyl-3-(arylamino)allyl)-4H-chromen-4-ones, by three-component domino reactions with (E)-3-(dimethylamino)-1-arylprop-2-en-1-ones and anilines under catalyst-free conditions.
• Facile and ecofriendly synthesis of new chromonyl chalcones.
• Synthesis of 3-(2-hydroxybenzoyl)quinolines and 7H-chromeno[3,2-c]quinolin-7-ones.

Packaging

5 g in glass bottle

Safety & Documentation

Safety Information

Personal Protective Equipment 
RIDADR 
NONH for all modes of transport
WGK Germany 
WGK 3
Flash Point(F) 
Not applicable
Flash Point(C) 
Not applicable
Protocols & Articles
Peer-Reviewed Papers
15

References

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