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383473 Sigma-Aldrich

3-Formyl-6-methylchromone

97%

Synonym: 6-Methyl-4-oxo-4H-1-benzopyran-3-carboxaldehyde

  • CAS Number 42059-81-4

  • Empirical Formula (Hill Notation) C11H8O3

  • Molecular Weight 188.18

  •  MDL number MFCD00138943

  •  PubChem Substance ID 24863971

  •  NACRES NA.22

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Properties

Related Categories Aldehydes, Benzopyrans, Building Blocks, C10-C12, Carbonyl Compounds,
Quality Level   100
assay   97%
mp   172-173 °C (lit.)
SMILES string   Cc1ccc2OC=C(C=O)C(=O)c2c1
InChI   1S/C11H8O3/c1-7-2-3-10-9(4-7)11(13)8(5-12)6-14-10/h2-6H,1H3
InChI key   GBWMIOYSMWCYIZ-UHFFFAOYSA-N

Description

General description

3-Formyl-6-methylchromone is a 3-formyl-substituted chromone. The combustion calorimetric estimation of the enthalpy of combustion of 3-formyl-6-methylchromone has been reported. Its anti-proliferative action on the MDR human colon cancer and mouse lymphoma has been investigated.

Application

3-Formyl-6-methylchromone has been used for the synthesis of 3-formyl-6-methylchromone-4-phenylthiosemicarbazone.

3-Formyl-6-methylchromone may be used in the preparation of series of Schiff′s bases, via reaction with aromatic sulfonamides, such as sulfanilamide, homosulfanilamide, 4-aminoethyl-benzenesulfonamide, a pyrimidinyl-substituted sulfanilamide derivative, sulfaguanidine and 4-amino-6-trifluoromethyl-benzene-1,3-disulfonamide. It may be used in the preparation of Schiff base, which undergoes addition reaction with diethyl phosphite to afford bis[(1,2,4,3-triazaphospholyl)(chromonyl)aminomethylphosphonate] derivative and bis[(1,2,4,3-triazaphospholyl)(chromonyl)phosphorylamino-methylphosphonate] derivative.

Packaging

5 g in glass bottle

Safety & Documentation

Safety Information

Personal Protective Equipment 
RIDADR 
NONH for all modes of transport
WGK Germany 
WGK 3
Flash Point(F) 
Not applicable
Flash Point(C) 
Not applicable
Protocols & Articles
Peer-Reviewed Papers
15

References

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