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389145 Sigma-Aldrich

(2-Hydroxypropyl)-β-cyclodextrin

average Mw ~1,540

Synonym: (2-Hydroxypropyl)-beta-cyclodextrin

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Properties

Related Categories Analytical Reagents, Analytical/Chromatography, Capillary Electrophoresis, Chelation/Complexation Compounds, Chemical Synthesis,
Quality Level   100
optical activity   [α]23/D +125°, c = 1 in H2O
mol wt   average Mw ~1,540
extent of labeling   1.0 molar substitution dextrin
SMILES string   CC(O)COCC1OC2OC3C(COCC(C)O)OC(OC4C(COCC(C)O)OC(OC5C(COCC(C)O)OC(OC6C(COCC(C)O)OC(OC7C(COCC(C)O)OC(OC8C(COCC(C)O)OC(OC1C(OCC(C)O)C2OCC(C)O)C(OCC(C)O)C8OCC(C)O)C(OCC(C)O)C7OCC(C)O)C(OCC(C)O)C6OCC(C)O)C(OCC(C)O)C5OCC(C)O)C(OCC(C)O)C4OCC(C)O)C(OCC(C)O)C3OCC(C)O
InChI key   ODLHGICHYURWBS-RYJYQAAZSA-N

Description

General description

(2-Hydroxypropyl)-β-cyclodextrin, a hydroxyalkyl derivative, is mainly used as a formulation vehicle to increase the dissolution of drugs in water for the successful delivery of medicinal agents to biological systems. It is commonly utilized as a substitute for α-, β- and γ-cyclodextrins.

Application

(2-Hydroxypropyl)-β-cyclodextrin may be used:
• As an analytical standard for the determination of the analyte in pharmaceutical formulations as well as nanoparticle formulations by thin layer chromatography (TLC) and high performance liquid chromatography (HPLC), respectively.
• To study the host-guest interaction with organic low molecular mass compounds prior to their quantification using reversed phase HPLC technique.
• As a mobile phase additive for the effective separation of β-carbolines by HPLC.
• In cyclodextrin-modified micellar electrokinetic chromatography (CD-modified MEKC) for the determination of sertraline hydrochloride and the synthesis-related products.
• As a chiral selector to resolve pantothenic acid by capillary electrophoresis.

The solubility of lipophilic drugs increases linearly with the concentration of hydroxypropyl-β-cyclodextrin (HBC) in aqueous solution because of the complex between HBC and the drug. This guest-host type complex is formed between the drug and the non-polar cavity in the HBC that results in enhanced solubility. Solutions may be lyophilized to produce freely soluble powders. Non-toxic in rabbits and mice.

Packaging

5, 25 g in poly bottle

Safety & Documentation

Safety Information

Personal Protective Equipment 
RIDADR 
NONH for all modes of transport
WGK Germany 
WGK 3
Flash Point(F) 
Not applicable
Flash Point(C) 
Not applicable

Documents

Certificate of Analysis (COA)

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Certificate of Origin (COO)

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Protocols & Articles
Peer-Reviewed Papers
15

References

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