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391263 Sigma-Aldrich

2-Dimethylaminoethanol

purified by redistillation, ≥99.5%

Synonym: N,N-Dimethyl-2-hydroxyethylamine, N,N-Dimethylethanolamine, DMEA, Jeffcat DMEA

  • CAS Number 108-01-0

  • Linear Formula (CH3)2NCH2CH2OH

  • Molecular Weight 89.14

  •  Beilstein/REAXYS Number 1209235

  •  EC Number 203-542-8

  •  MDL number MFCD00002846

  •  PubChem Substance ID 24864369

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Properties

Related Categories Amino Alcohols, Building Blocks, Chemical Synthesis, Organic Building Blocks, Oxygen Compounds More...
vapor pressure   100 mmHg ( 55 °C)
  6.12 mmHg ( 20 °C)
InChI Key   UEEJHVSXFDXPFK-UHFFFAOYSA-N
assay   ≥99.5%
purified by   redistillation
refractive index   n20/D 1.4294 (lit.)
bp   134-136 °C(lit.)
mp   −70 °C (lit.)
solubility   alcohol: miscible(lit.)
  water: soluble
density   0.886 g/mL at 20 °C (lit.)

Description

General description

2-Dimethylaminoethanol (DMAE/deanol) is an amino alcohol. It is the main product formed during the amination of ethylene glycol by dimethylamine on alumina supported copper in a continuous fixed-bed reactor. DMAE has been reported to be the putative precursor of acetylcholine. Its effect as a skin-firming and anti-wrinkle agent has been studied. Microwave spectrum of 2-dimethylaminoethanol has been investigated. Its effect as an organic additive on deposition and anti-reflective properties of porous CaF2 has been studied. Removal of the benzyl ester groups by transesterification with 2-dimethylaminoethanol from benzyl protected tripeptides has been reported.

Application

2-Dimethylaminoethanol (deanol) may be used as a ligand in the copper-catalyzed amination of aryl bromides and iodides.
2-Dimethylaminoethanol (deanol, DMAE, DMEA) may be used in the synthesis of the following:
• cis -[Co(sac)2(dmea)2] and cis -[Zn(sac)2(dmea)2] (sac=saccharinate)
• heterotrinuclear complex [Cu2Zn(NH3)I3(Me2Ea)3 (HMe2Ea=2-dimethylaminoethanol)
• 2-alkoxy-N,N-dimethylethylamine
• mixed-metal complexes of copper(II) and lead(II)

Packaging

100, 800 mL in Sure/Seal™

Safety & Documentation

Safety Information

Symbol 
Signal word 
Danger
Hazard statements 
RIDADR 
UN 2051 3(8) / PGII
WGK Germany 
1
RTECS 
KK6125000
Flash Point(F) 
102.2 °F
Flash Point(C) 
39 °C

Documents

Certificate of Analysis

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Certificate of Origin

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Meet Synthia - Retrosynthesis Sofware
Protocols & Articles
Peer-Reviewed Papers
15

References

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