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391468 Sigma-Aldrich

4-Hydroxypiperidine hydrochloride

98%

Synonym: 4-Piperidinol hydrochloride

  • CAS Number 5382-17-2

  • Empirical Formula (Hill Notation) C5H11NO · HCl

  • Molecular Weight 137.61

  •  Beilstein/REAXYS Number 3908995

  •  EC Number 226-374-7

  •  MDL number MFCD00035298

  •  PubChem Substance ID 24864381

  •  NACRES NA.22

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Properties

Related Categories Building Blocks, C5 to C7, Chemical Synthesis, Heterocyclic Building Blocks, Piperidines More...
assay   98%
mp   155-157 °C (lit.)
solubility   methanol: soluble 25 mg/mL, clear, colorless
storage temp.   room temp
SMILES string   Cl[H].OC1CCNCC1
InChI   1S/C5H11NO.ClH/c7-5-1-3-6-4-2-5;/h5-7H,1-4H2;1H
InChI key   VKCORPXOKYDINR-UHFFFAOYSA-N

Description

General description

4-Hydroxypiperidine hydrochloride is a piperidine derivative. The synthesis of 4-hydroxypiperidine has been reported. 4-Hydroxypiperidine participates in the synthesis of 4-(4′-hydroxypiperidino)-4-phenylcyclohexanol and 1-(4-hydroxypiperidino)cyclohexanecarbonitrile. 4-Hydroxypiperidine is the starting material for the synthesis of Sibrafiban and Lamifiban, two non-peptidefibrinogen receptor.

Application

4-Hydroxypiperidine hydrochloride is suitable for use in the Ugi-multi component reaction (MCR) to study the use of miniaturised-synthesis and Total Analysis System (mSYNTAS) in solution phase synthesis and on-line analysis of Ugi-MCRs. It may be used in the synthesis of acetic acid-piperidine-4-yl ester.

Reactant for synthesis of:
14C-labeled E4010
PET tracer for imaging brain acetylcholinesterase

Reactant for allosteric modulators of metabotropic glutamate receptor subtype 5

Packaging

5 g in glass bottle

Safety & Documentation

Safety Information

Symbol 
GHS07  GHS07
Signal word 
Warning
Hazard statements 
Precautionary statements 
Target organs 
Respiratory system
Personal Protective Equipment 
RIDADR 
NONH for all modes of transport
WGK Germany 
WGK 3
Flash Point(F) 
Not applicable
Flash Point(C) 
Not applicable
Protocols & Articles
Peer-Reviewed Papers
15

References

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