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  • 391611 - 7,8,9,10-Tetrahydrobenzo[a]pyren-7-ol

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391611 Sigma-Aldrich

7,8,9,10-Tetrahydrobenzo[a]pyren-7-ol

98%

  • CAS Number 6272-55-5

  • Empirical Formula (Hill Notation) C20H16O

  • Molecular Weight 272.34

  •  MDL number MFCD00192475

  •  PubChem Substance ID 24864391

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Properties

Related Categories Alcohols, Building Blocks, C11 to C30+, Chemical Synthesis, Organic Building Blocks,
InChI Key   VKUQFYXBPGXTKI-UHFFFAOYSA-N
assay   98%
mp   142-144 °C (lit.)

Description

General description

7,8,9,10-Tetrahydrobenzo[a]pyren-7-ol (7-hydroxy-7,8,9,10-tetrahydrobenzo[a]pyrene), a polycyclic aromatic hydrocarbon (PAH), is a substituted benzopyrene. Its bromination reaction with N-bromosaccharin (NBSac) has been investigated. The sulfotransferase-assisted activation of 7-hydroxy-7,8,9,10-tetrahydrobenzo[a]pyrene to form electrophilic, mutagenic, or tumorigenic sulfuric acid ester metabolite, which binds covalently to DNA and leads to mutation, has been reported.

Application

7,8,9,10-Tetrahydrobenzo[a]pyren-7-ol may be used as a starting material in the synthesis of (±)-trans-7,8-dihydroxy-6-fluoro-7,8-dihydrobenzo[a]pyrene.

Packaging

5 g in glass bottle

Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport
WGK Germany 
3
RTECS 
DJ8304000

Documents

Certificate of Analysis

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Protocols & Articles
Peer-Reviewed Papers
15

References

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