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39391 Sigma-Aldrich

N-(3-Dimethylaminopropyl)-N′-ethylcarbodiimide

≥97.0% (T)

Synonym: N-Ethyl-N′-(3-dimethylaminopropyl)carbodiimide, EDC, WSC

  • CAS Number 1892-57-5

  • Empirical Formula (Hill Notation) C8H17N3

  • Molecular Weight 155.24

  •  Beilstein/REAXYS Number 507429

  •  EC Number 217-579-2

  •  MDL number MFCD00044916

  •  PubChem Substance ID 57649895

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Properties

Related Categories Carbodiimides, Chemical Biology, Chemical Synthesis, Coupling, Peptide Coupling,
Quality Level   100
assay   ≥97.0% (T)
application(s)   peptide synthesis: suitable
refractive index   n20/D 1.461
density   0.877 g/mL at 20 °C (lit.)
storage temp.   −20°C
SMILES string   CCN=C=NCCCN(C)C
InChI   1S/C8H17N3/c1-4-9-8-10-6-5-7-11(2)3/h4-7H2,1-3H3
InChI key   LMDZBCPBFSXMTL-UHFFFAOYSA-N

Description

General description

N-(3-Dimethylaminopropyl)-N′-ethylcarbodiimide is commonly used in combination with N-hydroxysuccinimide (NHS) in carbodiimide coupling reaction to activate carboxyl group for coupling with amines to form amides.

Application

N-(3-Dimethylaminopropyl)-N′-ethylcarbodiimide has been used for the surface functionalization of graphene quantum dots (GQDs) employed as sensing probes in Janus micromotors to detect enterobacterial contamination. It has also been used for the activation of folic acid, prior to its conjugation on silica nanoparticles.

Packaging

10 mL in glass bottle

50 mL in Sure/Seal™

Other Notes

Tandem Mass Spectrometry data independently generated by Scripps Center for Metabolomics is available to view or download in PDF. 39391.pdf Tested metabolites are featured on Scripps Center for Metabolomics METLIN Metabolite Database. To learn more, visit sigma.com/metlin.

Safety & Documentation

Safety Information

Symbol 
GHS05  GHS05
Signal word 
Danger
Hazard statements 
Precautionary statements 
RIDADR 
UN 2735PSN1 8 / PGIII
WGK Germany 
WGK 3
Flash Point(F) 
Not applicable
Flash Point(C) 
Not applicable
Protocols & Articles

Articles

Carbodiimides

Carbodiimide-mediated peptide coupling remains to the most frequently used technique. As a major advantage, carbodiimides do not require prior activation of the carboxylic acid. Dicyclohexylcarbodiim...
Matthias Junkers
Aldrich ChemFiles 2007, 7.2, 5.
Keywords: Cyclizations, Peptide synthesis, Solid phase peptide synthesis

Tailoring Collagen-Based Matrices for Regenerative Medicine and Tissue Engineering

Jiayu Leong,1 Liam Grover,2 Hyunjoon Kong1* 1Department of Chemical and Biomolecular Engineering University of Illinois, Urbana-Champaign, IL 61801 USA 2University of Birmingham, UK *Email: hjkong06@...
Keywords: Adhesion, Adsorption, Aminations, Bacterial conjugations, Biomaterials, Building blocks, Cell culture, Clinical, Deaminations, Degradations, Deposition, Diffusion, Growth factors, Hydroxylations, Immobilization, Ligands, Methylations, Michael reaction, PAGE, Purification, Recombination, Reductive aminations, Transfection

Peer-Reviewed Papers
15

References

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