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394238 Sigma-Aldrich

Pyrrolidine

≥99.5%, purified by redistillation

Synonym: Tetrahydropyrrole, Tetramethyleneimine

  • CAS Number 123-75-1

  • Empirical Formula (Hill Notation) C4H9N

  • Molecular Weight 71.12

  •  Beilstein/REAXYS Number 102395

  •  EC Number 204-648-7

  •  MDL number MFCD00005249

  •  PubChem Substance ID 24864581

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Properties

Related Categories Building Blocks, C4 to C8, Cell Biology, Chemical Synthesis, Heterocyclic Building Blocks,
vapor density   2.45 (vs air)
vapor pressure   128 mmHg ( 39 °C)
  49 mmHg ( 20 °C)
InChI Key   RWRDLPDLKQPQOW-UHFFFAOYSA-N
assay   ≥99.5%
autoignition temp.   653 °F
purified by   redistillation
expl. lim.   10.6 %
refractive index   n20/D 1.443 (lit.)
bp   87-88 °C/760 mmHg(lit.)
solubility   water: miscible
density   0.852 g/mL at 25 °C (lit.)

Description

General description

Pyrrolidine is a five membered cyclic amine. It is a nitrogen heterocycle that forms the nucleus of various bioactive molecules. It can be synthesized by reacting 1,4-diaminobutanes with acids. It behaves as a strong base in employed in certain homogeneous nonaqueous reactions. Its crystalline structure has been investigated. Its reaction on the Ge(100)-2×1 surface and Si(100)-2×1 surface has been investigated. Pyrrolidine has been found to be one of the component of volatile amine fraction in the brewing process. A study on the kinetics of pyrrolidinolysis of phthalimide (PTH) shows second- and third-order terms in the rate law. Biodegradation of pyrrolidine by Mycobacterium strains has been studied.

Application

Pyrrolidine may be used in the following studies:
• Synthesis of pyrrolidine derivatives of pyrimidine.
• As a catalyst in the selective monoallylation of allylic alcohols.
• To capture carbondioxide in a bubble column reactor using pyrrolidine aqueous solutions by gas–liquid absorption.

Packaging

1 L in Sure/Seal™

100 mL in Sure/Seal™

Safety & Documentation

Safety Information

Symbol 
Signal word 
Danger
Hazard statements 
Precautionary statements 
RIDADR 
UN 1922 8(3) / PGII
WGK Germany 
2
RTECS 
UX9650000
Flash Point(F) 
37.4 °F
Flash Point(C) 
3 °C

Documents

Certificate of Analysis

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Certificate of Origin

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Milli-Q® Water Purification Solutions
Protocols & Articles
Peer-Reviewed Papers
15

References

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