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394963 Supelco

N,N-Dimethylformamide dimethyl acetal

for GC derivatization, LiChropur

Synonym: 1,1-Dimethoxytrimethylamine, 1,1-Dimethoxy-N,N-dimethylmethylamine

  • CAS Number 4637-24-5

  • Linear Formula (CH3)2NCH(OCH3)2

  • Molecular Weight 119.16

  •  Beilstein/REAXYS Number 506020

  •  EC Number 225-063-3

  •  MDL number MFCD00008482

  •  PubChem Substance ID 24864631

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Properties

Related Categories Acetals, Ketals & Ortho Esters, Alkylation Reagents, Amides, Amines, Analytical Reagents,
Quality Level   100
grade   for GC derivatization
assay   >95%
quality   LiChropur
refractive index   n20/D 1.396 (lit.)
bp   102-103 °C/720 mmHg (lit.)
density   0.897 g/mL at 25 °C (lit.)
reaction suitability   reagent type: derivatization reagent
reaction type: Acetylations
  reagent type: derivatization reagent
reaction type: Esterifications
SMILES string   COC(OC)N(C)C
InChI   1S/C5H13NO2/c1-6(2)5(7-3)8-4/h5H,1-4H3
InChI key   ZSXGLVDWWRXATF-UHFFFAOYSA-N

Description

General description

Esterate M (N,N-Dimethylformamide dimethyl acetal, DMFDMA) is an methylating reagent. It has been used in methyl esterification of carboxylic acid and also in one-step derivatization of amino acids into N,N-Dimethylaminomethylene methyl esters.

Packaging

10×1 mL in ampule

5, 25 mL in glass bottle

Application

It may be used in methylation of heterocyclic compounds which contains SH, NH, OH groups such as benzimidazole, naphth[2,3-c]imidazole, imidazo[4,5-c]-pyridine, purine, pyridine, pyrimidine, pyridazine and s-triazolo[4,3-b]pyridazine. It was used as derivatizing agent in a study to determine cocaine and benzoyl ecgonine in urine using GC with on-column alkylation.

Suitable for the derivatization of primary sulfonamides and trifluoroacetic acid.

Used in the preparation of formamidine derivatives, which are synthetic intermediates.

Used to catalyze the coupling of epoxides with carbon dioxide under solvent free conditions leading to cyclic carbonates.

Other Notes

Reagent for n-dimethylaminomethylene and methyl esters.

Safety & Documentation

Safety Information

Symbol 
Signal word 
Danger
Hazard statements 
RIDADR 
UN 3271 3 / PGII
WGK Germany 
WGK 1
Flash Point(F) 
42.8 °F
Flash Point(C) 
6 °C

Documents

Certificate of Analysis (COA)

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Certificate of Origin (COO)

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Meet Synthia - Retrosynthesis Sofware
Protocols & Articles
Peer-Reviewed Papers
15

References

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