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396494 Sigma-Aldrich

Aminoguanidine hydrochloride


Synonym: Guanylhydrazine hydrochloride

  • CAS Number 1937-19-5

  • Linear Formula NH2NHC(=NH)NH2 · HCl

  • Molecular Weight 110.55

  •  Beilstein Registry Number 3909606

  •  EC Number 217-707-7

  •  MDL number MFCD00039074

  •  PubChem Substance ID 24864672



Related Categories Building Blocks, Chemical Synthesis, Guanidines, Nitrogen Compounds, Organic Building Blocks More...
assay   ≥98%
mp   162-166 °C (lit.)


Biochem/physiol Actions

Inhibits both constitutive and inducible nitric oxide synthetase.


25, 100 g in glass bottle


Aminoguanidine hydrochloride may be employed as nitric oxide synthase (NOS) inhibitor to investigate its effect on the reduction of alveolar bone loss in ligature induced periodontitis in rats. It may be used in the synthesis of 5-guanylhydrazone derivatives, having antibacterial activity against antibacterial activity against both Escherichia coli and Staphylococcus aureus.

General description

Aminoguanidine hydrochloride has been reported in a study as inhibitor of animal nitric oxide (NO)-synthase. Crystal structure of aminoguanidine hydrochloride has been investigated by Fourier and least squares method. Its crystals were monoclinic and the guanidine part of the aminoguanidinium ion is planar.

Safety & Documentation

Safety Information

GHS07  GHS07
Signal word 
Hazard statements 
Precautionary statements 
Personal Protective Equipment 
NONH for all modes of transport
WGK Germany 


Certificate of Analysis

Certificate of Origin

Frequently Asked Questions

Which document(s) contains shelf-life or expiration date information for a given product?
If available for a given product, the recommended re-test date or the expiration date can be found on the Certificate of Analysis.
How do I get lot-specific information or a Certificate of Analysis?
The lot specific COA document can be found by entering the lot number above under the "Documents" section.
How do I find price and availability?
There are several ways to find pricing and availability for our products.Once you log onto our website, you will find the price and availability displayed on the product detail page.You can contact any of our Customer Sales and Service offices to receive a quote. USA customers: 1-800-325-3010 orview local office numbers.
Is there another aminoguanidine product suitable for cell culture?
Aminoguanidine hemisulfate salt, Product No. A7009, is water soluble, so it may be worth trying. But we do not offer an aminoguanidine product that has been cell culture tested by Sigma-Aldrich.
What impurities might be present in Product 396494, Aminoguanidine hydrochloride?
Malononitrile and urea might be present in minute amounts.
At what temperature should Product 396494, Aminoguanidine hydrochloride, be stored?
The material should be stored at room temperature.
What solvent can Product 396494, Aminoguanidine hydrochloride, be dissolved in?
This product is soluble in water at 50 mg/mL, yielding a clear, colorless to faint yellow solution. Heat may be required to get the material to dissolve at that concentration.
What is the Department of Transportation shipping information for this product?
Transportation information can be found in Section 14 of the product's (M)SDS.To access the shipping information for this material, use the link on the product detail page for the product.
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