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  • 39933 - (S)-4-Isopropylthiazolidine-2-thione

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39933 Sigma-Aldrich

(S)-4-Isopropylthiazolidine-2-thione

≥98.0%

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Properties

Related Categories Asymmetric Synthesis, Chemical Synthesis, Chiral Auxiliaries, Oxazolidinone Derivatives
InChI Key   CWIZUGZKLJDJLE-RXMQYKEDSA-N
assay   ≥98.0%
optical activity   [α]20/D -37±3°, c = 1 in chloroform
optical purity   ee: ≥99:1 (LC)
mp   69-71 °C

Description

Application

(S)-4-Isopropylthiazolidine-2-thione may be used as a chiral auxiliary for the stereochemical induction at the phosphorus atom during the diastereoselective synthesis of aryloxy phosphoramidate prodrugs of 3′-deoxy-2′,3′-didehydrothymidine monophosphate (d4TMP).

Evans-Type Oxazolidinethione And Thiazolidinethione Auxiliaries

A highly selective and efficient chiral auxiliary which can be directly reduced to its corresponding aldehyde and the chiral auxiliary by reductive cleavage with diisobutylaluminum hydride.

Packaging

2.5 g in glass bottle

Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport
WGK Germany 
3

Documents

Certificate of Analysis (COA)

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Protocols & Articles
Peer-Reviewed Papers
15

References

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