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405957 Sigma-Aldrich

Tris(1,1,1,3,3,3-hexafluoro-2-propyl) phosphite

98%

Synonym: Tris(2H-perfluoro-2-propyl) phosphite

  • CAS Number 66470-81-3

  • Linear Formula [(CF3)2CHO]3P

  • Molecular Weight 532.06

  •  Beilstein Registry Number 2315565

  •  MDL number MFCD00192561

  •  PubChem Substance ID 24865342

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Properties

Related Categories Building Blocks, Chemical Synthesis, Organic Building Blocks, Organic Phosphates/Phosphites, Phosphorus Compounds More...
InChI Key   MJOVEPJSFHDSOJ-UHFFFAOYSA-N
assay   98%
refractive index   n20/D 1.300(lit.)
bp   130 °C(lit.)
density   1.69 g/mL at 25 °C(lit.)

Description

Packaging

1 g in glass bottle

Application

Tris(1,1,1,3,3,3-hexafluoro-2-propyl) phosphite (tris(1,1,1,3,3,3-hexafluoroisopropyl) phosphite) may be used in the following processes:
• Preparation of new phosphonylating and coupling agents for the synthesis of oligodeoxyribonucleotides.
• Preparation of nucleoside H-phosphonate units.
• Synthesis of tetrakis(1,1,1,3,3,3-hexafluoroisopropoxy)(phenylthio)phosphorane by reacting with 1,1,1,3,3,3-hexafluoroisopropyl benzenesulfenate.

General description

Tris(1,1,1,3,3,3-hexafluoro-2-propyl) phosphite (tris(1,1,1,3,3,3-hexafluoroisopropyl) phosphite) is a sterically hindered, weakly σ-donating and strongly π-accepting ligand. It can be prepared by the reaction of lithium salt of 1,1,1,3,3,3-hexafluoro-2-propoxide with PCl3. It reacts with nucleosides to form deoxyribonucleoside 3′-bis(1,1,1,3,3,3-hexafluoro-2-propyl) phosphite units.

Safety & Documentation

Safety Information

Symbol 
GHS07  GHS07
Signal word 
Warning
Hazard statements 
Precautionary statements 
RIDADR 
NONH for all modes of transport
WGK Germany 
3

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