EMAIL THIS PAGE TO A FRIEND
417017 Sigma-Aldrich

Paclitaxel

From Taxus brevifolia, 95%

  • CAS Number 33069-62-4

  • Empirical Formula (Hill Notation) C47H51NO14

  • Molecular Weight 853.91

  •  Beilstein Registry Number 1420457

  •  MDL number MFCD00869953

  •  PubChem Substance ID 329756140

Purchase

Properties

Related Categories Antibiotics, Antibiotics A to Z, Antibiotics N-S, Antibiotics by Application, Antineoplastic and Immunosuppressive Antibiotics,
InChI Key   RCINICONZNJXQF-MZXODVADSA-N
assay   95%
optical activity   [α]20/D −49°, c = 1 in methanol
impurities   ≤1% methyl alcohol and ethyl alcohol
mp   213 °C (dec.) (lit.)
Mode of action   DNA synthesis | interferes
antibiotic activity spectrum   viruses
Gene Information   human ... BCL2(596)

Description

Caution

Paclitaxel undergoes transesterification in methanol and hydrolyzes in aqueous solutions.

Biochem/physiol Actions

Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase. The microtubule damage induces apoptosis through a JNK-dependent pathway followed by a JNK-independent pathway, perhaps related to the activation of protein kinase A (PKA) or of Raf-1 kinase, resulting in phosphorylation of Bcl-2. A major metabolite via CYP2CB is 6α-hydroxypaclitaxel (6α-OHP).

General description

Chemical structure: taxoide

Safety & Documentation

Safety Information

Symbol 
GHS08  GHS08
Signal word 
Danger
Hazard statements 
Precautionary statements 
RIDADR 
NONH for all modes of transport
WGK Germany 
3
RTECS 
DA8340700
Protocols & Articles
Peer-Reviewed Papers
15

References

Related Products

replaced by

Product #

Description

Add to Cart

T7402 Paclitaxel, from Taxus brevifolia, ≥95% (HPLC), powder

Technical Service:

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Bulk Ordering & Pricing:

Need larger quantities for your development, manufacturing or research applications?