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419362 Sigma-Aldrich

Di-tert-butyl N,N-diisopropylphosphoramidite

95%

  • CAS Number 137348-86-8

  • Linear Formula [(CH3)2CH]2NP[OC(CH3)3]2

  • Molecular Weight 277.38

  •  Beilstein/REAXYS Number 4858847

  •  MDL number MFCD00153506

  •  PubChem Substance ID 24866105

  •  NACRES NA.22

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Properties

Related Categories Catalysis and Inorganic Chemistry, Chemical Biology, Chemical Synthesis, Coupling Reagents, Nucleoside Chemistry,
assay   95%
refractive index   n20/D 1.444 (lit.)
bp   85-90 °C/0.2 mmHg (lit.)
density   0.879 g/mL at 25 °C (lit.)
functional group   phosphine
reaction suitability   reaction type: Buchwald-Hartwig Cross Coupling Reaction
  reaction type: Heck Reaction
  reaction type: Hiyama Coupling
  reaction type: Negishi Coupling
  reaction type: Sonogashira Coupling
  reaction type: Stille Coupling
  reaction type: Suzuki-Miyaura Coupling
  reagent type: ligand
storage temp.   2-8°C
SMILES string   CC(C)N(C(C)C)P(OC(C)(C)C)OC(C)(C)C
InChI   1S/C14H32NO2P/c1-11(2)15(12(3)4)18(16-13(5,6)7)17-14(8,9)10/h11-12H,1-10H3
InChI key   YGFLCNPXEPDANQ-UHFFFAOYSA-N

Description

Application

Di-tert-butyl N,N-diisopropylphosphoramidite is a general reagent to introduce tert-butyl-protected phosphate groups. It is commonly used in phosphorylation of biomolecules. It can also be used in the synthesis of phosphoramidate-linked glycoconjugates.

Packaging

1, 5 g in glass bottle

Safety & Documentation

Safety Information

Symbol 
GHS07  GHS07
Signal word 
Warning
Hazard statements 
Precautionary statements 
RIDADR 
NONH for all modes of transport
WGK Germany 
3
Flash Point(F) 
235.4 °F
Flash Point(C) 
113 °C
Protocols & Articles
Peer-Reviewed Papers
15

References

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