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439509 Sigma-Aldrich

3-Acetyl-2,5-dichlorothiophene

98%

Synonym: 2,5-Dichloro-3-thienyl methyl ketone

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Properties

Related Categories Building Blocks, C4 to C6, Chemical Synthesis, Halogenated Heterocycles, Heterocyclic Building Blocks,
InChI Key   GYFDNIRENHZKGR-UHFFFAOYSA-N
assay   98%
mp   37-40 °C (lit.)

Description

Packaging

5 g in glass bottle

Application

3-Acetyl-2,5-dichlorothiophene may be used in the following syntheses:
• substituted chalcones
• AL-4623A and AL-4862 (brinzolamide), inhibitors of topical carbonic anhydrase
• 2,5-dichlorothiophene-3-carboxylic acid, which is the starting reagent required for the synthesis of 2,5-dichloro-N-(substituted amino-carbonothioyl)thiophene-3-carboxamides and 2-(substituted amino)-4H-thieno[3,2-e]-1,3-thiazin-4-ones

Safety & Documentation

Safety Information

Symbol 
GHS07  GHS07
Signal word 
Warning
Hazard statements 
Precautionary statements 
Personal Protective Equipment 
RIDADR 
NONH for all modes of transport
WGK Germany 
3
Flash Point(F) 
235.4 °F
Flash Point(C) 
113 °C

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Protocols & Articles
Peer-Reviewed Papers
15

References

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