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  • 440140 - (3-Aminopropyl)triethoxysilane

440140 Sigma-Aldrich



Synonym: 3-Triethoxysilylpropylamine, APTES, APTS

  • CAS Number 919-30-2

  • Linear Formula H2N(CH2)3Si(OC2H5)3

  • Molecular Weight 221.37

  •  Beilstein/REAXYS Number 1754988

  •  EC Number 213-048-4

  •  MDL number MFCD00008207

  •  PubChem Substance ID 24867571

  •  NACRES NA.23



Related Categories Chemical Synthesis, Materials Science, Micro/NanoElectronics, Organometallic Reagents, Organosilicon,
Quality Level   200
assay   99%
form   liquid
bp   217 °C/760 mmHg (lit.)
density   0.946 g/mL at 25 °C (lit.)
InChI   1S/C9H23NO3Si/c1-4-11-14(12-5-2,13-6-3)9-7-8-10/h4-10H2,1-3H3


General description

(3-Aminopropyl)tiethoxysilane (APTES) is used as an amino-silane which is mainly used as a dispersant. APTES attaches an amino group to the functional silane for bio-conjugation.


Forms aminopropyl derivative of glass, an adsorbent for affinity chromatography. Used to prepare positively charged slides suitable for use with various immunohistochemical and in situ hybridization procedures. Recently (3-Aminopropyl)triethoxysilane has been used to prepare dye-doped silica nanoparticles with minimal aggregation and minimal nonspecific binding with biomolecules.

Self-assembled monolayer (SAM) of APTES can be used to improve the adhesion of graphene flakes and SiO2 to enable better contact with the metal electrodes. These electrodes may be used as electro-responsive tools for bio-sensing applications. It can be used to functionalize silane diazirine for fiber optic biosensor application. Hollow microcarriers (HMCs) can be surface modified with APTES which may be used for regenerative medicines and recombinant cells in biopharmaceutical industries.

Used in a preparation of a series of tenary composite films of polyimide/SiO/polydiphenylsiloxane with good optical transparency.


100, 500 mL in Sure/Seal™

Safety & Documentation

Safety Information

Signal word 
Hazard statements 
UN 2735PSN1 8 / PGII
WGK Germany 
Flash Point(F) 
199.4 °F - closed cup
Flash Point(C) 
93 °C - closed cup


Certificate of Analysis (COA)

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Certificate of Origin (COO)

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Frequently Asked Questions

Which document(s) contains shelf-life or expiration date information for a given product?
If available for a given product, the recommended re-test date or the expiration date can be found on the Certificate of Analysis.
How do I get lot-specific information or a Certificate of Analysis?
The lot specific COA document can be found by entering the lot number above under the "Documents" section.
What is the viscosity of Product 440140, APTES (3-Aminopropyl)triethoxysilane)?
According to our suppliers information the viscosity is 1.6 cS.
What is Product 440140, APTES (3-Aminopropyl)triethoxysilane) soluble in?
This product is soluble in water.
How should Product 440140, APTES (3-Aminopropyl)triethoxysilane) be stored?
We would recommend storing this product in accordance with our MSDS, which recommends storing at room temperature and under inert gas since this product is moisture sensitive.
What is the refractive index of Product 440140, APTES (3-Aminopropyl)triethoxysilane)?
According to our supplier the refractive index is 1.420.
How do I find price and availability?
There are several ways to find pricing and availability for our products. Once you log onto our website, you will find the price and availability displayed on the product detail page. You can contact any of our Customer Sales and Service offices to receive a quote. USA customers: 1-800-325-3010 or view local office numbers.
What is the Department of Transportation shipping information for this product?
Transportation information can be found in Section 14 of the product's (M)SDS.To access the shipping information for this material, use the link on the product detail page for the product.
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Protocols & Articles


Properties and Applications of Functionalized Graphene Oxide

1Claremont University, Keck Graduate Institute, School of Applied Life Sciences Claremont, CA 91711, USA 2Keck Science Department, Claremont McKenna College, Claremont, CA, 91711, USA 3Keck Science D...
Keywords: Adsorption, Amidations, Antibiotics, Antimicrobials, Bacterial conjugations, Cancer, Catalysis, Cell culture, Centrifugation, Clinical, Derivatizations, Detection methods, Diagnostic, Environmental, Esterifications, Filtration, Gas chromatography, Nanoelectronics, Nanomaterials, Nucleic acid denaturation, Nucleic acid hybridization, Nucleophilic additions, Oxidations, Polymerization reactions, Purification, Redox Reactions, Reductions, SN2 reaction, Semiconductor, Separation, Solar cells, Solvents, transformation

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