440744 Sigma-Aldrich


average Mn 80,000

Synonym: 2-Oxepanone homopolymer, 6-Caprolactone polymer

  • Linear Formula (C6H10O2)n

  •  NACRES NA.23



Related Categories 3D Printing Materials for Research and Development, Biodegradable Polymers, Biodegradeable Polymers for 3D Printing, Caprolactone Polymers, Homopolymers,
form   pellets (~3 mm)
mol wt   average Mn 80,000
impurities   <0.5% water
mp   60 °C (lit.)
density   1.145 g/mL at 25 °C
Mw/Mn   <2


General description

Polycaprolactone (PCL) is a semi crystalline hydrophobic biodegradable polyester which finds major applications as a drug delivery agent because of its cost efficiency, high toughness and biocompatibility. PCL possesses some unique properties such as:
• It degrades slower than other biodegradable polyesters in physiological condition, this property can be exploited in the controlled release of drugs in target tissues over a period of time.
• Its poor surface wetting and interaction with biological fluids on account of its hydrophobicity leads to poor cell adhesion and proliferation, hence it is blended with other synthetic /natural polymers.


• PCL loaded with antibiotics may be used to treat infections of the respiratory tract, like tuberculosis.
• Investigations were carried out based upon phenotypic responses of human bone marrow mesenchymal cells (hBMSCs) for different ratio of chitosan/ polycaprolactone (PCL) blends.
• PCL/biomedical ceramic materials have been studied for possible osteo tissue regeneration.
• Action of PCL/graded insulin/beta-5 glycerophosphate concentrations on osteochondral tissue formation through adipose-derived stromal cell differentiation.
• Other general uses include:extrusion aid, die lubricant, mold release, pigment and filler dispersion aid and polyester segments in urethanes and block polyesters.


5, 250, 500 g in poly bottle

Features and Benefits

Biodegradable polymer
Non-toxic, biodegradable in soil, broad miscibility, mechanical compatibility with many polymers and good adhesion to a broad spectrum of substrates.

Safety & Documentation

Safety Information

Personal Protective Equipment 
NONH for all modes of transport
WGK Germany 
Flash Point(F) 
Not applicable
Flash Point(C) 
Not applicable


Certificate of Analysis (COA)

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Certificate of Origin (COO)

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Protocols & Articles


3D Printing of Carbon Fiber-Reinforced Composites

3D printing is a type of additive manufacturing that can be used to rapidly fabricate components with highly customizable geometries, most typically using a layer-by-layer fabrication process. 3D pri...
Zhenyu Bo* (Ph.D Candidate at Northwestern University) and Jia Choi*, PhD, Product Manager

*Materials Science Product Management Team, MilliporeSigma, Milwaukee, WI.
Keywords: Deposition, Nanomaterials, Nanotubes

Biodegradable Aliphatic Polyesters for Drug Delivery

1Department of Chemistry and Biochemistry, University of Texas at Dallas, Richardson, TX 75080 2Department of Bioengineering, University of Texas at Dallas, Richardson, TX 75080 *Email: mihaela@utdal...
Vasanthy Karmegam,1 Pooneh Soltantabar,2 Erika Joy L. Calubaquib,1 Ruvanthi N. Kularatne,1 Mihaela C. Stefan1,2*
Material Matters, 2017, 12.2
Keywords: Bacterial conjugations, Biochemistry, Cancer, Catalysis, Clinical, Degradations, Electron spin resonance, Polymerization reactions, Reductions, Ring-opening polymerization, Solvents, Vitamins

Biomaterials Tutorial

Biocompatible Polymers Biodegradable Polymers Crosslinkers Biocompatible Inorganic Materials Supramolecular Chemistry
Keywords: Agriculture, Antimicrobials, Biomaterials, Ceramics, Chromatography, Cosmetics, Degradations, Diffusion, Environmental, Genomics, Germination, Nanomaterials, Oxidations, Petrochemical, Pharmaceutical, Polymerization reactions, Proteomics, Reductions

Bioprinting for Tissue Engineering and Regenerative Medicine

Chi-Chun Pan,1,2 Arnaud Bruyas,1 Yunzhi Peter Yang1,3,4 Departments of 1Orthopedic Surgery, 2Mechanical Engineering, 3Materials Science and Engineering, and 4Bioengineering Stanford University, 300 P...
Chi-Chun Pan, Arnaud Bruyas, Yunzhi Peter Yang
Material Matters, 2016, 11.2
Keywords: Biomaterials, Cancer, Cell attachment, Clinical, Deposition, Growth factors, Pharmaceutical

Three-Dimensional Printing of Tissue Engineering Scaffolds

Helena N. Chia, Ph.D.,1* Benjamin M. Wu, D.D.S, Ph.D.1,2* 1Department of Bioengineering, Henry Samueli School of Engineering University of California, Los Angeles, CA 90095 USA 2Division of Advanced ...
Keywords: Biomaterials, Ceramics, Chromatin immunoprecipitation, Deposition, Diagnostic Imaging, Diffusion, Growth factors, Materials Science, Melting, Polymerization reactions, Solvents

Peer-Reviewed Papers


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