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  • 447439 - 1-Methyl-L-tryptophan

447439 Sigma-Aldrich



  • CAS Number 21339-55-9

  • Empirical Formula (Hill Notation) C12H14N2O2

  • Molecular Weight 218.25

  •  MDL number MFCD00467133

  •  PubChem Substance ID 24868339

  •  NACRES NA.22



Related Categories Amino Acids & Derivatives, Chemical Biology, Chemical Synthesis, Peptide Synthesis and Peptide Chemistry, Tryptophan More...
Quality Level   100
assay   95%
optical activity   [α]24/D −8.0°, c = 2 in acetic acid
application(s)   peptide synthesis: suitable
mp   242-245 °C (lit.)
SMILES string   Cn1cc(C[C@H](N)C(O)=O)c2ccccc12
InChI   1S/C12H14N2O2/c1-14-7-8(6-10(13)12(15)16)9-4-2-3-5-11(9)14/h2-5,7,10H,6,13H2,1H3,(H,15,16)/t10-/m0/s1



1-Methyl-L-tryptophan can be used:
• In the preparation of L-tryptophan-based ligand for regioselective copper catalyzed N2-arylation of 1,2,3-triazoles.
• As a key starting material for the total synthesis of (−)-ardeemin.
• In the synthesis of cyclic peptide-capped gold nanoparticles as drug delivery systems.


1, 5 g in glass bottle

Safety & Documentation

Safety Information

Personal Protective Equipment 
NONH for all modes of transport
WGK Germany 
Flash Point(F) 
Not applicable
Flash Point(C) 
Not applicable


Certificate of Analysis (COA)

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Certificate of Origin (COO)

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Frequently Asked Questions

Which document(s) contains shelf-life or expiration date information for a given product?
If available for a given product, the recommended re-test date or the expiration date can be found on the Certificate of Analysis.
How do I get lot-specific information or a Certificate of Analysis?
The lot specific COA document can be found by entering the lot number above under the "Documents" section.
How do I find price and availability?
There are several ways to find pricing and availability for our products. Once you log onto our website, you will find the price and availability displayed on the product detail page. You can contact any of our Customer Sales and Service offices to receive a quote. USA customers: 1-800-325-3010 or view local office numbers.
What is the Department of Transportation shipping information for this product?
Transportation information can be found in Section 14 of the product's (M)SDS.To access the shipping information for this material, use the link on the product detail page for the product.
How do you recommend dissolving Product No. 447439, 1-Methyl-L-tryptophan?
This product is soluble in 0.5 N Hydrochloric acid at 50 mg/mL. Based on information from one of our customers (not confirmed in our labs), this product is also soluble in 0.1 N sodium hydroxide at a 20 mM concentration. It is not soluble in DMSO.
What conditions do you recommend for long term storage of Product No. 447439, 1-Methyl-L-tryptophan?
The long term storage temperature of the product 447139 is at room temperature. This information can be found in the MSDS sheet. This document is available from our website.
The name of Product No. 447439 is "1-Methyl-L-tryptophan, 95%". How is that purity value determined?
The purity of Product No. 447439 is based on elemental analysis. That is, the assayed values for percent carbon and nitrogen should be within about 95% of their theoretical values. But the speification sheet does not report an overall purity value per se.
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