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465119 Sigma-Aldrich

Baicalein

98%

Synonym: 5,6,7-Trihydroxyflavone

  • CAS Number 491-67-8

  • Empirical Formula (Hill Notation) C15H10O5

  • Molecular Weight 270.24

  •  Beilstein Registry Number 272683

  •  MDL number MFCD00017459

  •  PubChem Substance ID 24870246

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Properties

Related Categories Building Blocks, C15 to C38, Cancer Research, Carbonyl Compounds, Cell Biology,
InChI Key   FXNFHKRTJBSTCS-UHFFFAOYSA-N
assay   98%
mp   256-271 °C (lit.)
Gene Information   mouse ... Hexa(15211)
rat ... Alox15(81639), Alox5(25290)

Description

Biochem/physiol Actions

The flavonoid component of Nepalese and Sino-Japanese crude drugs. Baicalein, a major flavone of Scutellariae baicalensis, inhibits the 12-lipoxygenase (12-LOX) pathway of arachidonic acid metabolism, which inhibits cancer cell proliferation and induces apoptosis.

Packaging

100, 500 mg in amber glass bottle

Application

Baicalein was used in a study to investigate the in vitro quantitative inhibition of lipoxygenase.

General description

Baicalein, a flavonoid, is a xanthine oxidase inhibitor. Anti-inflammatory effects of baicalein in peripheral human leukocytes has been studied.

Other Notes

Tandem Mass Spectrometry data independently generated by Scripps Center for Metabolomics is available to view or download in PDF. 465119.pdf Tested metabolites are featured on Scripps Center for Metabolomics METLIN Metabolite Database. To learn more, visit sigma.com/metlin.

Safety & Documentation

Safety Information

Personal Protective Equipment 
RIDADR 
NONH for all modes of transport
WGK Germany 
3

Documents

Certificate of Analysis

Certificate of Origin


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Protocols & Articles

Articles

Dietary Antioxidants

Antioxidants protect biological systems from oxidative damage produced by oxygen-containing free radicals and from redoxactive transition metal ions such as iron, copper, and cadmium.1 During the oxi...
Biofiles Volume 2 Article 2
Keywords: Adhesion, Anti-inflammatory agents, Applications, Cancer, Cardiovascular, Catalysis, Diabetes, Diseases, Gene expression, Metabolism, Neurodegenerative Diseases, Peroxidations, Phosphorylations, Prebiotics, Probiotics, Reductions, Transcription, Transduction, Vitamins

HPLC Analysis of Flavones on Discovery® HS PEG

From our library of Articles, Sigma-Aldrich presents HPLC Analysis of Flavones on Discovery® HS PEG
Keywords: Chromatography, High performance liquid chromatography

Peer-Reviewed Papers
15

References

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