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465119 Sigma-Aldrich

Baicalein

98%

Synonym: 5,6,7-Trihydroxyflavone

  • CAS Number 491-67-8

  • Empirical Formula (Hill Notation) C15H10O5

  • Molecular Weight 270.24

  •  Beilstein/REAXYS Number 272683

  •  MDL number MFCD00017459

  •  PubChem Substance ID 24870246

  •  NACRES NA.22

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Properties

Related Categories Building Blocks, C15 to C38, Cancer Research, Carbonyl Compounds, Cell Biology,
assay   98%
mp   256-271 °C (lit.)
storage temp.   room temp
SMILES string   Oc1cc2OC(=CC(=O)c2c(O)c1O)c3ccccc3
InChI   1S/C15H10O5/c16-9-6-11(8-4-2-1-3-5-8)20-12-7-10(17)14(18)15(19)13(9)12/h1-7,17-19H
InChI key   FXNFHKRTJBSTCS-UHFFFAOYSA-N
Gene Information   mouse ... Hexa(15211)
rat ... Alox15(81639), Alox5(25290)

Description

General description

Baicalein, a flavonoid, is a xanthine oxidase inhibitor. Anti-inflammatory effects of baicalein in peripheral human leukocytes has been studied.

Application

Baicalein was used in a study to investigate the in vitro quantitative inhibition of lipoxygenase.

Packaging

100, 500 mg in amber glass bottle

Biochem/physiol Actions

The flavonoid component of Nepalese and Sino-Japanese crude drugs. Baicalein, a major flavone of Scutellariae baicalensis, inhibits the 12-lipoxygenase (12-LOX) pathway of arachidonic acid metabolism, which inhibits cancer cell proliferation and induces apoptosis.

Other Notes

Tandem Mass Spectrometry data independently generated by Scripps Center for Metabolomics is available to view or download in PDF. 465119.pdf Tested metabolites are featured on Scripps Center for Metabolomics METLIN Metabolite Database. To learn more, visit sigma.com/metlin.

Safety & Documentation

Safety Information

Personal Protective Equipment 
RIDADR 
NONH for all modes of transport
WGK Germany 
WGK 3
Flash Point(F) 
Not applicable
Flash Point(C) 
Not applicable

Documents

Certificate of Analysis (COA)

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Certificate of Origin (COO)

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Protocols & Articles

Articles

Dietary Antioxidants

Antioxidants protect biological systems from oxidative damage produced by oxygen-containing free radicals and from redoxactive transition metal ions such as iron, copper, and cadmium.1 During the oxi...
Biofiles Volume 2 Article 2
Keywords: Adhesion, Anti-inflammatory agents, Applications, Cancer, Cardiovascular, Catalysis, Diabetes, Diseases, Gene expression, Metabolism, Neurodegenerative Diseases, Peroxidations, Phosphorylations, Prebiotics, Probiotics, Reductions, Transcription, Transduction, Vitamins

HPLC Analysis of Flavones on Discovery® HS PEG

From our library of Articles, Sigma-Aldrich presents HPLC Analysis of Flavones on Discovery® HS PEG
Keywords: Chromatography, High performance liquid chromatography

Peer-Reviewed Papers
15

References

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