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47561 Sigma-Aldrich

Fmoc-Trp(Boc)-OH

≥97.0% (HPLC)

Synonym: Nα-Fmoc-N(in)-Boc-L-tryptophan, N(in)-Boc-Nα-Fmoc-L-tryptophan

  • CAS Number 143824-78-6

  • Empirical Formula (Hill Notation) C31H30N2O6

  • Molecular Weight 526.58

  •  Beilstein/REAXYS Number 7698009

  •  MDL number MFCD00153366

  •  eCl@ss 32160406

  •  PubChem Substance ID 57651011

  •  NACRES NA.26

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Properties

Related Categories Amino Acids & Derivatives, Chemical Biology, Chemical Synthesis, Peptide Synthesis and Peptide Chemistry, Standard Fmoc Amino Acids,
Quality Level   100
assay   ≥97.0% (HPLC)
optical activity   [α]20/D −21±2°, c = 1% in DMF
application(s)   peptide synthesis: suitable
storage temp.   2-8°C
SMILES string   CC(C)(C)OC(=O)n1cc(C[C@H](NC(=O)OCC2c3ccccc3-c4ccccc24)C(O)=O)c5ccccc15
InChI   1S/C31H30N2O6/c1-31(2,3)39-30(37)33-17-19(20-10-8-9-15-27(20)33)16-26(28(34)35)32-29(36)38-18-25-23-13-6-4-11-21(23)22-12-5-7-14-24(22)25/h4-15,17,25-26H,16,18H2,1-3H3,(H,32,36)(H,34,35)/t26-/m0/s1
InChI key   ADOHASQZJSJZBT-SANMLTNESA-N

Description

Application

Fmoc-Trp(Boc)-OH can be used for the synthesis of analogs of glucagon-like peptide-1 (GLP-1) for the treatment of type 2 diabetes and various peptides by Fmoc solid phase peptide synthesis (SPPS).

Packaging

5, 25 g in poly bottle

Safety & Documentation

Safety Information

Personal Protective Equipment 
RIDADR 
NONH for all modes of transport
WGK Germany 
WGK 3
Flash Point(F) 
Not applicable
Flash Point(C) 
Not applicable

Documents

Certificate of Analysis (COA)

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Protocols & Articles

Articles

Natural Amino Acid Building Blocks for Peptide Synthesis

With a growing peptide drug market the fast, reliable and uncomplicated synthesis of peptides is of paramount importance.1 Today, the most common synthetic approaches to medium and even large peptide...
Matthias Junkers
ChemFiles 2008, 8.7, 22.
Keywords: Building blocks, Peptide synthesis, Peptidomimetics, Solid phase peptide synthesis

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Indoles, Purines, and Their Isosteres

Substituted indoles and purines have frequently been referred to as “privileged structures” since they are capable of binding to multiple receptors with high affinity, and thus have applications acro...
Keywords: Building blocks, Medicinal chemistry

Peer-Reviewed Papers
15

References

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