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47625 Sigma-Aldrich

Fmoc-Glu(OtBu)-OH

≥98.0% (HPLC)

Synonym: Fmoc-L-glutamic acid 5-tert-butyl ester

  • CAS Number 71989-18-9

  • Empirical Formula (Hill Notation) C24H27NO6

  • Molecular Weight 425.47

  •  Beilstein/REAXYS Number 3636375

  •  EC Number 276-253-8

  •  MDL number MFCD00037135

  •  eCl@ss 32160406

  •  PubChem Substance ID 57651045

  •  NACRES NA.26

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Properties

Related Categories Amino Acids & Derivatives, Chemical Biology, Chemical Synthesis, Glutamic Acid, Peptide Synthesis and Peptide Chemistry,
InChI Key   OTKXCALUHMPIGM-FQEVSTJZSA-N
assay   ≥98.0% (HPLC)
optical activity   [α]20/D −5.0±2.0°, c = 1% in acetic acid: water (4:1)
impurities   ~4% water
storage temp.   2-8°C

Description

Application

Fmoc-Glu(OtBu)-OH (Fmoc-L-glutamic acid 5-tert-butyl ester) can be employed as a:
• Ligand in the synthesis of cis-substituted cyclopropane carboxylic acids via C-H activation of cyclopropane carboxamides using Pd catalyst.
• Linker in the preparation of multi-small molecule-conjugated PTX (paclitaxel) derivatives.

It can be also used as a building block in the preparation of stapled α-helical peptides , and peptide C-terminal thioesters .

Packaging

1 kg in poly bottle

10, 25, 100 g in poly bottle

Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport
WGK Germany 
3

Documents

Certificate of Analysis (COA)

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Protocols & Articles

Articles

Natural Amino Acid Building Blocks for Peptide Synthesis

With a growing peptide drug market the fast, reliable and uncomplicated synthesis of peptides is of paramount importance.1 Today, the most common synthetic approaches to medium and even large peptide...
Matthias Junkers
ChemFiles 2008, 8.7, 22.
Keywords: Building blocks, Peptide synthesis, Peptidomimetics, Solid phase peptide synthesis

Peer-Reviewed Papers
15

References

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