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476994 Sigma-Aldrich

5-Bromoisatin

technical grade, 90%

  • CAS Number 87-48-9

  • Empirical Formula (Hill Notation) C8H4BrNO2

  • Molecular Weight 226.03

  •  Beilstein Registry Number 383760

  •  EC Number 201-747-7

  •  MDL number MFCD00005719

  •  PubChem Substance ID 24871320

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Properties

Related Categories Building Blocks, C7 to C9, Chemical Synthesis, Halogenated Heterocycles, Heterocyclic Building Blocks,
grade   technical grade
InChI Key   MBVCESWADCIXJN-UHFFFAOYSA-N
assay   90%
impurities   <10% isatin
mp   247-252 °C (lit.)

Description

Packaging

5, 25 g in glass bottle

Application

5-Bromoisatin may be used in the synthesis of the following:
• N-derivatives of 5-bromoisatin
• N-substituted pyrroles
• linear polyaryleneoxindoles
• 5-bromodioxindole
• cinchoninic acid derivatives
• 3-hydroxyoxindole
• S-benzyldithiocarbazate Schiff Bases
• 5-bromooxindole
• Morita-Baylis-Hillman adducts of isatin derivatives

General description

5-Bromoisatin is a 5-haloisatin. One of the methods reported for its synthesis is by reacting N-halosaccharins with isatin in the presence of SiO2. Its inotropic activity has been studied on rhythmically stimulated papillary muscles of guinea pigs. It is reported to exhibit analgesic and sedative properties at a dose of 0.2g/kg in mice.

Safety & Documentation

Safety Information

Symbol 
GHS07  GHS07
Signal word 
Warning
Hazard statements 
Precautionary statements 
Personal Protective Equipment 
RIDADR 
NONH for all modes of transport
WGK Germany 
2
RTECS 
NL7875000

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Protocols & Articles
Peer-Reviewed Papers
15

References

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