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477028 Sigma-Aldrich

2-Hydroxyethyl methacrylate

≥99%, contains ≤50 ppm monomethyl ether hydroquinone as inhibitor

Synonym: 1,2-Ethanediol mono(2-methylpropenoate), Glycol methacrylate, HEMA

  • CAS Number 868-77-9

  • Linear Formula CH2=C(CH3)COOCH2CH2OH

  • Molecular Weight 130.14

  •  Beilstein/REAXYS Number 1071583

  •  MDL number MFCD00002863

  •  PubChem Substance ID 24871325

  •  NACRES NA.23



Related Categories 3D Printing Materials for Research and Development, Acrylic Monomers, Building Blocks, C6 to C7, Carbonyl Compounds,
Quality Level   200
vapor density   5 (vs air)
vapor pressure   0.01 mmHg ( 25 °C)
assay   ≥99%
contains   ≤50 ppm monomethyl ether hydroquinone as inhibitor
refractive index   n20/D 1.453 (lit.)
bp   67 °C/3.5 mmHg (lit.)
density   1.073 g/mL at 25 °C (lit.)
storage temp.   2-8°C
SMILES string   CC(=C)C(=O)OCCO
InChI   1S/C6H10O3/c1-5(2)6(8)9-4-3-7/h7H,1,3-4H2,2H3


General description

2-Hydroxyethyl methacrylate (HEMA) is biocompatible in nature. Polymeric hydrogel scaffold can be produced by polymerizing HEMA in water.


A polymeric hydrogel for drug delivery. Patent has been applied for the development of artificial cornea or KPro, it is composed of pHEMA (polymerized from HEMA) and poly (methyl methacrylate)(PMMA). HEMA may be used as a macromonomer for the synthesis of 2-hydroxyethylmethacrylate-poly(ε-caprolactone) (HEMA-PCL) by coordinated anionic ring opening polymerization (ROP). 


25, 100 mL in poly bottle

Safety & Documentation

Safety Information

GHS07  GHS07
Signal word 
Hazard statements 
NONH for all modes of transport
WGK Germany 
Flash Point(F) 
222.8 °F - closed cup
Flash Point(C) 
106 °C - closed cup
Protocols & Articles


3D Printing of Carbon Fiber-Reinforced Composites

3D printing is a type of additive manufacturing that can be used to rapidly fabricate components with highly customizable geometries, most typically using a layer-by-layer fabrication process. 3D pri...
Zhenyu Bo* (Ph.D Candidate at Northwestern University) and Jia Choi*, PhD, Product Manager

*Materials Science Product Management Team, MilliporeSigma, Milwaukee, WI.
Keywords: Deposition, Nanomaterials, Nanotubes

Bioactive Hydrogels

The first report of the synthesis of composite materials comprising conducting polymers and hydrogels was in 1994 by Wallace et al.1 Their objective was to enhance the porosity and ion-transport prop...
Anthony Guiseppi-Elie
Material Matters 2006, 1.1, 8.
Keywords: Adsorption, Applications, Automotive, Biomaterials, Emulsion polymerization, Enzyme activity, Growth factors, Hydration reaction, Immobilization, Polymerization reactions, Support

The Progress in Development of Dental Restorative Materials

With dentists placing nearly 100 million dental fillings into patients′ teeth annually in the U.S. alone, polymeric composite restoratives account for a very large share of the biomaterials market. T...
Jeffrey Stansbury1* and Christopher Bowman2
Material Matters 2010, 5.3, 73.
Keywords: Adhesion, Biomaterials, Infrared spectroscopy, Nanomaterials, Polymerization reactions, Reductions, Separation, Sol-gel, Spectroscopy

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Peer-Reviewed Papers


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