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480894 Sigma-Aldrich

O-(Tetrahydro-2H-pyran-2-yl)hydroxylamine

96%

  • CAS Number 6723-30-4

  • Empirical Formula (Hill Notation) C5H11NO2

  • Molecular Weight 117.15

  •  MDL number MFCD01321374

  •  PubChem Substance ID 24871725

  •  NACRES NA.22

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Properties

Related Categories Building Blocks, Chemical Synthesis, Heterocyclic Building Blocks, Pyrans
assay   96%
bp   81 °C/20 mmHg (lit.)
mp   34-37 °C (lit.)
SMILES string   NOC1CCCCO1
InChI   1S/C5H11NO2/c6-8-5-3-1-2-4-7-5/h5H,1-4,6H2
InChI key   NLXXVSKHVGDQAT-UHFFFAOYSA-N

Description

General description

O-(Tetrahydro-2H-pyran-2-yl)hydroxylamine (OTX) is an O-substituted hydroxylamine. The coupling of OTX with alkaline gel electrophoresis has been reported to improve the process of detecting single strand breaks (SSBs) in DNA.

Application

O-(Tetrahydro-2H-pyran-2-yl)hydroxylamine may be used in the synthesis of 2-(5-bromothiophene-2-sulfonamido)-N-(tetrahydro-2H-pyran-2-yloxy)acetamides.
It may be used in the synthesis of the following potential histone deacetylase (HDAC) inhibitors:
• 2-[1-(naphthalene-2-sulfonyl)-heterocyclyl]-pyrimidine-5-carboxylic acid (tetrahydropyran-2-yloxy)-amides
• (E)-3-(2-benzyl-1-oxoisoindolin-6-yl)-N-(tetrahydro-2H-pyran-2-yloxy)acrylamide
• 3-(1-benzenesulfonyl-2,3-dihydro-1H-indol-5-yl)-N-hydroxy-acrylamide

Packaging

1 g in glass bottle

Safety & Documentation

Safety Information

Symbol 
GHS07  GHS07
Signal word 
Warning
Hazard statements 
Precautionary statements 
Personal Protective Equipment 
RIDADR 
NONH for all modes of transport
WGK Germany 
3
Flash Point(F) 
179.6 °F
Flash Point(C) 
82 °C

Documents

Certificate of Analysis (COA)

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Certificate of Origin (COO)

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Meet Synthia - Retrosynthesis Sofware
Protocols & Articles
Peer-Reviewed Papers
15

References

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