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488712 Aldrich

Trimethyl(trifluoromethyl)silane

99%

Synonym: (Trifluoromethyl)trimethylsilane, Ruppert’s Reagent, TFMTMS

  • CAS Number 81290-20-2

  • Linear Formula (CH3)3SiCF3

  • Molecular Weight 142.19

  •  Beilstein Registry Number 4241868

  •  MDL number MFCD00145454

  •  PubChem Substance ID 24872418

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Properties

Related Categories C-C Bond Formation, Chemical Synthesis, Fluorination Reagents, Organometallic Reagents, Organosilicon,
InChI Key   MWKJTNBSKNUMFN-UHFFFAOYSA-N
assay   99%
bp   54-55 °C(lit.)
density   0.962 g/mL at 20 °C(lit.)
storage temp.   2-8°C

Description

Packaging

5, 25 mL in glass bottle

Application

Trimethyl(trifluoromethyl)silane can be used as a trifluoromethylating agent in the following processes:
• Conversion of N-(tert-butylsulfinyl)-imines to trifluoromethylated amines• Conversion of trans-enones to trans-α-trifluoromethyl silyl ethers• Trifluoromethylation of azomethine imines• Conversion of H-phosphonates to CF3-phosphonates• Nucleophilic addition of the trifluoromethyl group to aldehydes and ketones.<REFERENCE ID="84178" TYPE="literature"/>

Safety & Documentation

Safety Information

Symbol 
GHS02  GHS02
Signal word 
Danger
Hazard statements 
Precautionary statements 
RIDADR 
UN 1993BF 3 / PGII
WGK Germany 
3
Flash Point(F) 
1.4 °F
Flash Point(C) 
-17 °C

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Protocols & Articles

Articles

Acids and Bases

Acids and bases have been used by chemists for centuries, and are among the most fundamental reagents employed in synthetic organic chemistry. This Aldrich product line ranges from Brønsted and Lewis...
Chemfiles Volume 1 Article 3

Baran Reagents FAQs

What do the Baran reagents do? Allow the placement of alkyl groups onto molecules in drug discovery by replacing a C-H bond with the corresponding C-C bond (trifluoromethyl, difluoromethyl, isopropyl...
Keywords: Agrochemicals, Alkylations, Drug discovery, Fluorinations, Liquid chromatography mass spectrometry, Medicinal chemistry, Nuclear magnetic resonance spectroscopy, PAGE, Solvents

Reagents for C–C Bond Formation

Aldrich carries a large variety of electrophiles and nucleophiles that are widely used in C–C bond-forming reactions. This group of products contains many organometallic reagents as well as commonly-...
ChemFiles Volume 1 Article 3
Keywords: Acylations, Alkylations

Reagents for Fluorination

The trifluoromethyl substituent has long been recognized for the positive influence it can have on the biological activity of molecules. Professor William Dolbier, Jr. (University of Florida) has dev...
Aldrich ChemFiles 2007, 7.1, 11.

Peer-Reviewed Papers
15

References

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